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Effect of COVID-19 on Endocrine Glands Function.
Endokrinologya ; 27(1):14-22, 2022.
Article in Bulgarian | EMBASE | ID: covidwho-2284218
ABSTRACT
A new hitherto unknown virus called severe acute respiratory syndrome coronavirus-2, SARS-CoV-2 for short, the causative agent of the disease COVID-19, has swept the world and become pandemic in its spread. Penetration of the virus into host cells is accomplished by attachment of the spike protein of the virus to its receptor, ACE-2, an enzyme of the renin angiotensin aldosterone system (RAAS), a zinc-dependent carboxypeptidase, which is expressed predominantly in the lung, heart, vascular endothelium, kidney, adipose tissue, thyroid, hypothalamus, pituitary, adrenal pancreas, ovary and testis. SARS-CoV-2 exerts its adverse effects on the function of all endocrine glands, either by direct (viral-toxic) or indirect (immune) mechanisms, with the strength of its action being modulated mainly by hormones of the pituitary-hypothalamic-adrenal axis and also involving the RAAS. This review discusses in detail the impact of SARS-CoV-2 on the endocrine system and possible future complications. The aim is to answer whether SARS-CoV-2 causes endocrine disease per se and whether an increase in the incidence of endocrine disease is expected after rechallenge with COVID-19.Copyright © 2022 Medical Information Center. All rights reserved.
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Collection: Databases of international organizations Database: EMBASE Type of study: Experimental Studies Language: Bulgarian Journal: Endokrinologya Year: 2022 Document Type: Article

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Collection: Databases of international organizations Database: EMBASE Type of study: Experimental Studies Language: Bulgarian Journal: Endokrinologya Year: 2022 Document Type: Article