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Characterization of SARS-CoV-2 Omicron BA.2.75 clinical isolates.
Uraki, Ryuta; Iida, Shun; Halfmann, Peter J; Yamayoshi, Seiya; Hirata, Yuichiro; Iwatsuki-Horimoto, Kiyoko; Kiso, Maki; Ito, Mutsumi; Furusawa, Yuri; Ueki, Hiroshi; Sakai-Tagawa, Yuko; Kuroda, Makoto; Maemura, Tadashi; Kim, Taksoo; Mine, Sohtaro; Iwamoto, Noriko; Li, Rong; Liu, Yanan; Larson, Deanna; Fukushi, Shuetsu; Watanabe, Shinji; Maeda, Ken; Wang, Zhongde; Ohmagari, Norio; Theiler, James; Fischer, Will; Korber, Bette; Imai, Masaki; Suzuki, Tadaki; Kawaoka, Yoshihiro.
  • Uraki R; Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, 108-8639, Japan.
  • Iida S; The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute, Tokyo, 162-8655, Japan.
  • Halfmann PJ; Department of Pathology, National Institute of Infectious Diseases, Tokyo, 162-8640, Japan.
  • Yamayoshi S; Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, 53711, USA.
  • Hirata Y; Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, 108-8639, Japan.
  • Iwatsuki-Horimoto K; The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute, Tokyo, 162-8655, Japan.
  • Kiso M; Department of Pathology, National Institute of Infectious Diseases, Tokyo, 162-8640, Japan.
  • Ito M; Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, 108-8639, Japan.
  • Furusawa Y; Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, 108-8639, Japan.
  • Ueki H; Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, 108-8639, Japan.
  • Sakai-Tagawa Y; Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, 108-8639, Japan.
  • Kuroda M; The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute, Tokyo, 162-8655, Japan.
  • Maemura T; Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, 108-8639, Japan.
  • Kim T; The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute, Tokyo, 162-8655, Japan.
  • Mine S; Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, 108-8639, Japan.
  • Iwamoto N; Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, 53711, USA.
  • Li R; Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, 53711, USA.
  • Liu Y; Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, 53711, USA.
  • Larson D; Department of Pathology, National Institute of Infectious Diseases, Tokyo, 162-8640, Japan.
  • Fukushi S; Disease Control and Prevention Center, National Center for Global Health and Medicine Hospital, Tokyo, 162-8655, Japan.
  • Watanabe S; Department of Animal, Dairy, and Veterinary Sciences, College of Agriculture and Applied Sciences, Utah State University, Logan, UT, 84322, USA.
  • Maeda K; Department of Animal, Dairy, and Veterinary Sciences, College of Agriculture and Applied Sciences, Utah State University, Logan, UT, 84322, USA.
  • Wang Z; Department of Animal, Dairy, and Veterinary Sciences, College of Agriculture and Applied Sciences, Utah State University, Logan, UT, 84322, USA.
  • Ohmagari N; Department of Virology 1, National Institute of Infectious Diseases, Musashimurayama, Tokyo, 208-0011, Japan.
  • Theiler J; Center for Influenza and Respiratory Virus Research, National Institute of Infectious Diseases, Musashimurayama, Tokyo, 208-0011, Japan.
  • Fischer W; Department of Veterinary Science, National Institute of Infectious Diseases, Tokyo, 162-8640, Japan.
  • Korber B; Department of Animal, Dairy, and Veterinary Sciences, College of Agriculture and Applied Sciences, Utah State University, Logan, UT, 84322, USA.
  • Imai M; Disease Control and Prevention Center, National Center for Global Health and Medicine Hospital, Tokyo, 162-8655, Japan.
  • Suzuki T; Space Data Science and Systems, Los Alamos National Laboratory, Los Alamos, NM, 87545, USA.
  • Kawaoka Y; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM, 87545, USA.
Nat Commun ; 14(1): 1620, 2023 03 23.
Article in English | MEDLINE | ID: covidwho-2284921
ABSTRACT
The prevalence of the Omicron subvariant BA.2.75 rapidly increased in India and Nepal during the summer of 2022, and spread globally. However, the virological features of BA.2.75 are largely unknown. Here, we evaluated the replicative ability and pathogenicity of BA.2.75 clinical isolates in Syrian hamsters. Although we found no substantial differences in weight change among hamsters infected with BA.2, BA.5, or BA.2.75, the replicative ability of BA.2.75 in the lungs is higher than that of BA.2 and BA.5. Of note, BA.2.75 causes focal viral pneumonia in hamsters, characterized by patchy inflammation interspersed in alveolar regions, which is not observed in BA.5-infected hamsters. Moreover, in competition assays, BA.2.75 replicates better than BA.5 in the lungs of hamsters. These results suggest that BA.2.75 can cause more severe respiratory disease than BA.5 and BA.2 in a hamster model and should be closely monitored.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Topics: Variants Limits: Animals Country/Region as subject: Asia Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2023 Document Type: Article Affiliation country: S41467-023-37059-x

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Topics: Variants Limits: Animals Country/Region as subject: Asia Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2023 Document Type: Article Affiliation country: S41467-023-37059-x