Neuroinflammation and Oxidative Stress in the Pathogenesis of Autism Spectrum Disorder.
Int J Mol Sci
; 24(6)2023 Mar 13.
Article
in English
| MEDLINE | ID: covidwho-2284960
ABSTRACT
Autism spectrum disorder (ASD) is a neurodevelopmental disorder (NDD) characterized by impairments in social communication, repetitive behaviors, restricted interests, and hyperesthesia/hypesthesia caused by genetic and/or environmental factors. In recent years, inflammation and oxidative stress have been implicated in the pathogenesis of ASD. In this review, we discuss the inflammation and oxidative stress in the pathophysiology of ASD, particularly focusing on maternal immune activation (MIA). MIA is a one of the common environmental risk factors for the onset of ASD during pregnancy. It induces an immune reaction in the pregnant mother's body, resulting in further inflammation and oxidative stress in the placenta and fetal brain. These negative factors cause neurodevelopmental impairments in the developing fetal brain and subsequently cause behavioral symptoms in the offspring. In addition, we also discuss the effects of anti-inflammatory drugs and antioxidants in basic studies on animals and clinical studies of ASD. Our review provides the latest findings and new insights into the involvements of inflammation and oxidative stress in the pathogenesis of ASD.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Prenatal Exposure Delayed Effects
/
Autism Spectrum Disorder
Type of study:
Prognostic study
Topics:
Long Covid
Limits:
Animals
/
Female
/
Humans
/
Pregnancy
Language:
English
Year:
2023
Document Type:
Article
Affiliation country:
Ijms24065487
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