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SARS-CoV-2 Effects on Psychophysical Olfactory Scores: Prospective Study With Evaluation Before and 60-Days After Infection.
Vaira, Luigi Angelo; Lechien, Jerome R; Salzano, Giovanni; Maglitto, Fabio; Boscolo-Rizzo, Paolo; Hopkins, Claire; De Riu, Giacomo.
  • Vaira LA; Maxillofacial Surgery Operative Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.
  • Lechien JR; Biomedical Science Department, PhD School of Biomedical Science, University of Sassari, Sassari, Italy.
  • Salzano G; Department of Anatomy and Experimental Oncology, Mons School of Medicine, Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium.
  • Maglitto F; Department of Otolaryngology-Head Neck Surgery, Elsan Polyclinic of Poitiers, Poitiers, France.
  • Boscolo-Rizzo P; Maxillofacial Surgery Operative Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.
  • Hopkins C; Department of Maxillofacial Surgery, University of Naples "Federico II", Naples, Italy.
  • De Riu G; Maxillofacial Surgery Operative Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.
Otolaryngol Head Neck Surg ; 168(5): 1249-1252, 2023 05.
Article in English | MEDLINE | ID: covidwho-2285028
ABSTRACT
The aim of this study was to prospectively evaluate the olfactory function in a series of individuals infected with SARS-CoV-2 and who had undergone psychophysical olfactory assessment prior to infection. Individuals unexposed to SARS-CoV-2 infection underwent a psychophysical evaluation of smell with the Sniffin' Sticks test. The subjects were followed prospectively and included in the study if they developed SARS-CoV-2 infection with a second test 60 days after recovery. At the 60-day follow-up of the 41 included subjects, 2 (4.9%) self-reported persistent olfactory dysfunction (OD). The differences between TDI scores before and after infection were statistically significant (37 [interquartile range (IQR), 34.25-39.25] vs 34.75 [IQR, 32.25-38]; p = .021). Analyzing the individual olfactory domains, the differences were significant for threshold (T) (9.75 [IQR, 9-11.25] vs 8.25 [IQR, 7.25-10.25]; p = .009) but not for odor discrimination (D) (p = .443) and identification (I) (p = .159). SARS-CoV-2 causes a significant reduction in the olfactory function, in particular affecting the olfactory threshold, even in subjects who do not self-report an OD.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Olfaction Disorders Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Otolaryngol Head Neck Surg Journal subject: Otolaryngology Year: 2023 Document Type: Article Affiliation country: Ohn.166

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Olfaction Disorders Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Otolaryngol Head Neck Surg Journal subject: Otolaryngology Year: 2023 Document Type: Article Affiliation country: Ohn.166