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[18F]FDG-PET/CT in mechanically ventilated critically ill patients with COVID-19 ARDS and persistent inflammation.
van Leer, Bram; van Snick, Johannes H; Londema, Mark; Nijsten, Maarten W N; Kasalak, Ömer; Slart, Riemer H J A; Glaudemans, Andor W J M; Pillay, Janesh.
  • van Leer B; Groningen, The Netherlands Medical Imaging Center, Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen.
  • van Snick JH; TA29, PO box: 30 001, 9700 RB Groningen, The Netherlands Department of Critical Care, University Medical Center Groningen, University of Groningen.
  • Londema M; Groningen, The Netherlands Medical Imaging Center, Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen.
  • Nijsten MWN; Groningen, The Netherlands Medical Imaging Center, Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen.
  • Kasalak Ö; TA29, PO box: 30 001, 9700 RB Groningen, The Netherlands Department of Critical Care, University Medical Center Groningen, University of Groningen.
  • Slart RHJA; TA29, PO box: 30 001, 9700 RB Groningen, The Netherlands Department of Critical Care, University Medical Center Groningen, University of Groningen.
  • Glaudemans AWJM; Groningen, The Netherlands Department of Radiology, University Medical Center Groningen, University of Groningen.
  • Pillay J; Groningen, The Netherlands Medical Imaging Center, Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen.
Clin Transl Imaging ; 11(3): 297-306, 2023.
Article in English | MEDLINE | ID: covidwho-2285180
ABSTRACT

Purpose:

We report the findings of four critically ill patients who underwent an [18F]FDG-PET/CT because of persistent inflammation during the late phase of their COVID-19.

Methods:

Four mechanically ventilated patients with COVID-19 were retrospectively discussed in a research group to evaluate the added value of [18F]FDG-PET/CT.

Results:

Although pulmonary PET/CT findings differed, bilateral lung anomalies could explain the increased CRP and leukocytes in all patients. This underscores the limited ability of the routine laboratory to discriminate inflammation from secondary infections. Based on PET/CT findings, a secondary infection/inflammatory focus was suspected in two patients (pancreatitis and gastritis). Lymphadenopathy was present in patients with a detectable SARS-CoV-2 viral load. Muscle uptake around the hips or shoulders was observed in all patients, possibly due to the process of heterotopic ossification.

Conclusion:

This case series illustrates the diagnostic potential of [18F]FDG-PET/CT imaging in critically ill patients with persistent COVID-19 for the identification of other causes of inflammation and demonstrates that this technique can be performed safely in mechanically ventilated critically ill patients.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies Topics: Long Covid Language: English Journal: Clin Transl Imaging Year: 2023 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies Topics: Long Covid Language: English Journal: Clin Transl Imaging Year: 2023 Document Type: Article