Neuroinflammation and COVID-19.
Curr Opin Neurobiol
; 76: 102608, 2022 10.
Article
in English
| MEDLINE | ID: covidwho-2285205
ABSTRACT
Coronavirus disease 2019 (COVID-19) has caused a historic pandemic of respiratory disease. COVID-19 also causes acute and post-acute neurological symptoms, which range from mild, such as headaches, to severe, including hemorrhages. Current evidence suggests that there is no widespread infection of the central nervous system (CNS) by SARS-CoV-2, thus what is causing COVID-19 neurological disease? Here, we review potential immunological mechanisms driving neurological disease in COVID-19 patients. We begin by discussing the implications of imbalanced peripheral immunity on CNS function. Next, we examine the evidence for dysregulation of the blood-brain barrier during SARS-CoV-2 infection. Last, we discuss the role myeloid cells may play in promoting COVID-19 neurological disease. Combined, we highlight the role of innate immunity in COVID-19 neuroinflammation and suggest areas for future research.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
/
Nervous System Diseases
Topics:
Long Covid
Limits:
Humans
Language:
English
Journal:
Curr Opin Neurobiol
Journal subject:
Biology
/
Neurology
Year:
2022
Document Type:
Article
Affiliation country:
J.conb.2022.102608
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