Sex differences in neuromuscular disorders.
Mech Ageing Dev
; 211: 111793, 2023 04.
Article
in English
| MEDLINE | ID: covidwho-2285604
ABSTRACT
The prevalence, onset, pathophysiology, and clinical course of many neuromuscular disorders (NMDs) may significantly differ between males and females. Some NMDs are more frequently observed in females, and characterized to show a higher grade of severity during or after the pregnancy. Meanwhile, others tend to have an earlier onset in males and exhibit a more variable progression. Prevalently, sex differences in NMDs have a familiar character given from genetic inheritance. However, they may also influence clinical presentation and disease severity of acquired NMD forms, and are represented by both hormonal and genetic factors. Consequently, to shed light on the distinctive role of biological factors in the different clinical phenotypes, we summarize in this review the sex related differences and their distinctive biological roles emerging from the current literature in both acquired and inherited NMDs.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Sex Characteristics
/
Neuromuscular Diseases
Type of study:
Observational study
/
Prognostic study
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Mech Ageing Dev
Year:
2023
Document Type:
Article
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