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Advanced in-vitro test setup for valved holding chambers with pediatric facemasks
European Respiratory Journal Conference: European Respiratory Society International Congress, ERS ; 60(Supplement 66), 2022.
Article in English | EMBASE | ID: covidwho-2286832
ABSTRACT
Due to the non-pharmacological interventions to control the COVID-19 pandemic increased and more severe respiratory syncytial virus (RSV) infections occurred worldwide due to the inadequate training of the immune system in small children. As viral infections are associated with the exacerbation of childhood wheezing and asthma, safe and efficient inhalation therapy in asthmatic children is essential. PARI has developed an advanced high-repeatability test set-up for pMDI with valved holding chamber (VHC) and masks to investigate therapy efficiency. The study presents the aerosol performance of budesonide (BUD) and salbutamol (SAL) pMDIs with PARI's VORTEX and masks according to USP <1602>. A standardized setup and methodology mimicking clinically relevant conditions with minimized operator variability as used in this study is key for realistic VHC testing. Tests were performed using VORTEXwith Babymask Ladybug (0-2 yrs.) or Childmask Frog (2-4 yrs.) and ageappropriate baby and child face models. Both models mimic facial geometry and tissue softness and were connected to a next generation impactor. VORTEXand pMDIs (Sutanol, GSK;Budiair, Chiesi) were mounted in an automated shake-and-fire setup and applied with a contact force of 16 N. Tests were carried out with validated HPLC analysis (n=12). Fine particle dose (FPD, <5mum) was more than doubled for VORTEXwith Babymask Ladybug (FPD=22.4%) and Childmask Frog (FPD=23.8%) compared to pMDI alone (FPD=10.9%) for BUD and increased by =30% for SAL. Throat deposition of both active substances nebulized using VORTEX+ mask was reduced to <0.3% compared to >60% for pMDIs alone. Mask size does not influence the performance of the aerosol significantly.
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Full text: Available Collection: Databases of international organizations Database: EMBASE Language: English Journal: European Respiratory Journal Conference: European Respiratory Society International Congress, ERS Year: 2022 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: EMBASE Language: English Journal: European Respiratory Journal Conference: European Respiratory Society International Congress, ERS Year: 2022 Document Type: Article