Acute Cardiac Events During COVID-19-Associated Hospitalizations.
J Am Coll Cardiol
; 81(6): 557-569, 2023 02 14.
Article
in English
| MEDLINE | ID: covidwho-2286964
ABSTRACT
BACKGROUND:
COVID-19 is associated with cardiac complications.OBJECTIVES:
The purpose of this study was to estimate the prevalence, risk factors, and outcomes associated with acute cardiac events during COVID-19-associated hospitalizations among adults.METHODS:
During January 2021 to November 2021, medical chart abstraction was conducted on a probability sample of adults hospitalized with laboratory-confirmed SARS-CoV-2 infection identified from 99 U.S. counties in 14 U.S. states in the COVID-19-Associated Hospitalization Surveillance Network. We calculated the prevalence of acute cardiac events (identified by International Classification of Diseases-10th Revision-Clinical Modification codes) by history of underlying cardiac disease and examined associated risk factors and disease outcomes.RESULTS:
Among 8,460 adults, 11.4% (95% CI 10.1%-12.9%) experienced an acute cardiac event during a COVID-19-associated hospitalization. Prevalence was higher among adults who had underlying cardiac disease (23.4%; 95% CI 20.7%-26.3%) compared with those who did not (6.2%; 95% CI 5.1%-7.6%). Acute ischemic heart disease (5.5%; 95% CI 4.5%-6.5%) and acute heart failure (5.4%; 95% CI 4.4%-6.6%) were the most prevalent events; 0.3% (95% CI 0.1%-0.5%) experienced acute myocarditis or pericarditis. Risk factors varied by underlying cardiac disease status. Patients with ≥1 acute cardiac event had greater risk of intensive care unit admission (adjusted risk ratio 1.9; 95% CI 1.8-2.1) and in-hospital death (adjusted risk ratio 1.7; 95% CI 1.3-2.1) compared with those who did not.CONCLUSIONS:
Acute cardiac events were common during COVID-19-associated hospitalizations, particularly among patients with underlying cardiac disease, and are associated with severe disease outcomes. Persons at greater risk for experiencing acute cardiac events during COVID-19-associated hospitalizations might benefit from more intensive clinical evaluation and monitoring during hospitalization.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
/
Heart Diseases
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
Topics:
Long Covid
Limits:
Adult
/
Humans
Language:
English
Journal:
J Am Coll Cardiol
Year:
2023
Document Type:
Article
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