Your browser doesn't support javascript.
Impact of inactivated vaccines on decrease of viral RNA levels in individuals with the SARS-CoV-2 Omicron (BA.2) variant: A retrospective cohort study in Shanghai, China.
Yang, Peng; Dang, Bianli; Kang, Wen; Li, Xiaofeng; Wang, Tianping; Li, Ruijuan; Peng, Meijuan; Liu, Yushen; Wang, Linxu; Cheng, Yan; Yu, Suhuai; Wei, Min; Gao, Han; Kang, Wenzhen; Shang, Lei.
  • Yang P; Department of Health Statistics, Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, Xi'an, China.
  • Dang B; Department of Infectious Diseases, The Second Affiliated Hospital, Fourth Military Medical University, Xi'an, China.
  • Kang W; Department of Infectious Diseases, The Second Affiliated Hospital, Fourth Military Medical University, Xi'an, China.
  • Li X; Department of Infectious Diseases, The Second Affiliated Hospital, Fourth Military Medical University, Xi'an, China.
  • Wang T; Department of Infectious Diseases, The Second Affiliated Hospital, Fourth Military Medical University, Xi'an, China.
  • Li R; Department of Infectious Diseases, The Second Affiliated Hospital, Fourth Military Medical University, Xi'an, China.
  • Peng M; Department of Infectious Diseases, The Second Affiliated Hospital, Fourth Military Medical University, Xi'an, China.
  • Liu Y; Department of Infectious Diseases, The Second Affiliated Hospital, Fourth Military Medical University, Xi'an, China.
  • Wang L; Department of Infectious Diseases, The Second Affiliated Hospital, Fourth Military Medical University, Xi'an, China.
  • Cheng Y; Department of Infectious Diseases, The Second Affiliated Hospital, Fourth Military Medical University, Xi'an, China.
  • Yu S; Department of Infectious Diseases, The Second Affiliated Hospital, Fourth Military Medical University, Xi'an, China.
  • Wei M; Department of Infectious Diseases, The Second Affiliated Hospital, Fourth Military Medical University, Xi'an, China.
  • Gao H; The Third Regiment, Basic Medical Science Academy, Fourth Military Medical University, Xi'an, China.
  • Kang W; Department of Infectious Diseases, The Second Affiliated Hospital, Fourth Military Medical University, Xi'an, China.
  • Shang L; Department of Health Statistics, Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, Xi'an, China.
Front Public Health ; 11: 1107343, 2023.
Article in English | MEDLINE | ID: covidwho-2287561
ABSTRACT

Background:

SARS-CoV-2 Omicron (BA.2) has stronger infectivity and more vaccine breakthrough capability than previous variants. Few studies have examined the impact of inactivated vaccines on the decrease of viral RNA levels in individuals with the Omicron variant, based on individuals' continuous daily cycle threshold (Ct) values and associated medical information from the infection to hospital discharge on a large population.

Methods:

We extracted 39,811 individuals from 174,371 Omicron-infected individuals according to data inclusion and exclusion criteria. We performed the survival data analysis and Generalized Estimating Equation to calculate the adjusted relative risk (aRR) to assess the effect of inactivated vaccines on the decrease of viral RNA levels.

Results:

Negative conversion was achieved in 54.7 and 94.3% of all infected individuals after one and 2 weeks, respectively. aRRs were shown weak effects on turning negative associated with vaccinations in asymptomatic infections and a little effect in mild diseases. Vaccinations had a protective effect on persistent positivity over 2 and 3 weeks. aRRs, attributed to full and booster vaccinations, were both around 0.7 and had no statistical significance in asymptomatic infections, but were both around 0.6 with statistical significance in mild diseases, respectively. Trends of viral RNA levels among vaccination groups were not significant in asymptomatic infections, but were significant between unvaccinated group and three vaccination groups in mild diseases.

Conclusion:

Inactivated vaccines accelerate the decrease of viral RNA levels in asymptomatic and mild Omicron-infected individuals. Vaccinated individuals have lower viral RNA levels, faster negative conversion, and fewer persisting positive proportions than unvaccinated individuals. The effects are more evident and significant in mild diseases than in asymptomatic infections.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Asymptomatic Infections / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines / Variants Limits: Humans Country/Region as subject: Asia Language: English Journal: Front Public Health Year: 2023 Document Type: Article Affiliation country: Fpubh.2023.1107343

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Asymptomatic Infections / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines / Variants Limits: Humans Country/Region as subject: Asia Language: English Journal: Front Public Health Year: 2023 Document Type: Article Affiliation country: Fpubh.2023.1107343