Clinical characteristics of Guillain-Barre syndrome in COVID-19: a systematic review and meta-analysis of observational studies.
Egypt J Neurol Psychiatr Neurosurg
; 59(1): 40, 2023.
Article
in English
| MEDLINE | ID: covidwho-2288164
ABSTRACT
Background:
Guillain-Barre syndrome (GBS) is a complication that occurs in patients with Coronavirus Disease (COVID-19) infection. The spectrum of symptoms varies from mild to severe symptoms, even death. The study aimed to compare the clinical manifestations in GBS patients with and without COVID-19 comorbidity.Results:
A systematic review and meta-analysis of cohort and cross-sectional studies was conducted comparing the characteristics and course of GBS disease in the COVID-19 positive and COVID-19 negative groups. Four articles were selected with a total sample of 61 COVID-19 positive and 110 COVID-19 negative GBS patients. Based on clinical manifestations, COVID-19 infection increased the likelihood of tetraparesis (OR 2.54; 95% CI 1.12-5.74; p = 0.03) and the presence of facial nerve involvement (OR 2.34; 95% CI 1.00-5.47; p = 0.05). Demyelinating type GBS or AIDP was more common in the COVID-19 positive group (OR 2.32; 95% CI 1.16-4.61; p = 0.02). COVID-19 in GBS significantly increased the need for intensive care (OR 3.32; 95% CI 1.48-7.46; p = 0.004) and the use of mechanical ventilation (OR 2.42; 95% CI 1.00-5.86; p = 0.05).Conclusions:
GBS following COVID-19 infection showed more severe variations in clinical characteristics compared to the group of GBS patients without COVID-19. Early detection of GBS, especially the typical manifestations post COVID-19 infection, is very important to carry out intensive monitoring and early management before the patient's condition worsens.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
/
Reviews
/
Systematic review/Meta Analysis
Topics:
Long Covid
Language:
English
Journal:
Egypt J Neurol Psychiatr Neurosurg
Year:
2023
Document Type:
Article
Affiliation country:
S41983-023-00633-7
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