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Global Dynamics of Porcine Enteric Coronavirus PEDV Epidemiology, Evolution, and Transmission.
Zhang, Hao; Zou, Chuangchao; Peng, Ouyang; Ashraf, Usama; Xu, Qiuping; Gong, Lang; Fan, Baochao; Zhang, Yun; Xu, Zhichao; Xue, Chunyi; Wei, Xiaona; Zhou, Qingfeng; Tian, Xiaoyan; Shen, Hanqin; Li, Bin; Zhang, Xiangbin; Cao, Yongchang.
  • Zhang H; State Key Laboratory of Biocontrol, Life Sciences School, Sun Yat-sen University, Guangzhou, China.
  • Zou C; State Key Laboratory of Biocontrol, Life Sciences School, Sun Yat-sen University, Guangzhou, China.
  • Peng O; State Key Laboratory of Biocontrol, Life Sciences School, Sun Yat-sen University, Guangzhou, China.
  • Ashraf U; State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
  • Xu Q; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
  • Gong L; State Key Laboratory of Biocontrol, Life Sciences School, Sun Yat-sen University, Guangzhou, China.
  • Fan B; Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
  • Zhang Y; Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Nanjing, China.
  • Xu Z; State Key Laboratory of Biocontrol, Life Sciences School, Sun Yat-sen University, Guangzhou, China.
  • Xue C; State Key Laboratory of Biocontrol, Life Sciences School, Sun Yat-sen University, Guangzhou, China.
  • Wei X; State Key Laboratory of Biocontrol, Life Sciences School, Sun Yat-sen University, Guangzhou, China.
  • Zhou Q; State Key Laboratory of Biocontrol, Life Sciences School, Sun Yat-sen University, Guangzhou, China.
  • Tian X; Guangdong Enterprise Key Laboratory for Animal Health and Environmental Control, Wen's Group Academy, Wen's Foodstuff Group Co. Ltd, Yunfu, China.
  • Shen H; Guangdong Enterprise Key Laboratory for Animal Health and Environmental Control, Wen's Group Academy, Wen's Foodstuff Group Co. Ltd, Yunfu, China.
  • Li B; Guangdong Enterprise Key Laboratory for Animal Health and Environmental Control, Wen's Group Academy, Wen's Foodstuff Group Co. Ltd, Yunfu, China.
  • Zhang X; Guangdong Enterprise Key Laboratory for Animal Health and Environmental Control, Wen's Group Academy, Wen's Foodstuff Group Co. Ltd, Yunfu, China.
  • Cao Y; Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Nanjing, China.
Mol Biol Evol ; 40(3)2023 03 04.
Article in English | MEDLINE | ID: covidwho-2288520
ABSTRACT
With a possible origin from bats, the alphacoronavirus Porcine epidemic diarrhea virus (PEDV) causes significant hazards and widespread epidemics in the swine population. However, the ecology, evolution, and spread of PEDV are still unclear. Here, from 149,869 fecal and intestinal tissue samples of pigs collected in an 11-year survey, we identified PEDV as the most dominant virus in diarrheal animals. Global whole genomic and evolutionary analyses of 672 PEDV strains revealed the fast-evolving PEDV genotype 2 (G2) strains as the main epidemic viruses worldwide, which seems to correlate with the use of G2-targeting vaccines. The evolving pattern of the G2 viruses presents geographic bias as they evolve tachytely in South Korea but undergo the highest recombination in China. Therefore, we clustered six PEDV haplotypes in China, whereas South Korea held five haplotypes, including a unique haplotype G. In addition, an assessment of the spatiotemporal spread route of PEDV indicates Germany and Japan as the primary hubs for PEDV dissemination in Europe and Asia, respectively. Overall, our findings provide novel insights into the epidemiology, evolution, and transmission of PEDV, and thus may lay a foundation for the prevention and control of PEDV and other coronaviruses.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Coronavirus Infections / Coronavirus / Porcine epidemic diarrhea virus / Alphacoronavirus Type of study: Observational study / Randomized controlled trials Topics: Vaccines Limits: Animals Language: English Journal subject: Molecular Biology Year: 2023 Document Type: Article Affiliation country: Molbev

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Coronavirus Infections / Coronavirus / Porcine epidemic diarrhea virus / Alphacoronavirus Type of study: Observational study / Randomized controlled trials Topics: Vaccines Limits: Animals Language: English Journal subject: Molecular Biology Year: 2023 Document Type: Article Affiliation country: Molbev