Study on the effect of Xuanfei Jiere Granules in the treatment of COVID-19 by network pharmacology and molecular docking
Northwest Pharmaceutical Journal
; 37(6):71-80, 2022.
Article
in Chinese
| CAB Abstracts | ID: covidwho-2288679
ABSTRACT
Objective:
To explore the effect and mechanism of Xuanfei Jiere Granules in the treatment of corona virus disease 2019 (COVID-19) complicated with fever.Methods:
The effective components of Xuanfei Jiere Granules were screened by Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), and the potential target genes were predicted. The disease targets of COVID-19 complicated with fever were searched by GeneCards and CTD databases, and the common targets were obtained, and then introduced into Cytoscape to construct the "component-target-disease" network. The above 2 common targets were input into the online database of STRING protein interaction, and the results were imported into Cytoscape software to obtain Protein-Protein Interaction(PPI) network;R language was used to analyze the common targets with Gene Ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) enrichment analysis.Results:
84 active components and 82 targets were obtained. The pathway enrichment analysis showed that Xuanfei Jiere Granules mainly acted on protein kinase B(AKT1), tumor protein P53(TP53), interleukin-6(IL6) and other key targets in the treatment of COVID-19 complicated with fever. KEGG pathway enrichment analysis showed that the action was mainly related to the influence of fluid shear stress and atherosclerosis, human cytomegalovirus infection, and AGE-RAGE in diabetic complications and other signal pathways. The results of molecular docking showed that the core target had strong affinity with beta-sitosterol, formononetin, N-trans ferulyl tyramine and so on.Conclusion:
This study preliminarily verified that Xuanfei Jiere Granules can play a role in the treatment of COVID-19 complicated with fever through multi-components, multi-targets and multi-pathways.
Pesticides and Drugs, Control [HH405], Non-food/Non-feed Plant Products [SS200], Prion; Viral; Bacterial and Fungal Pathogens of Humans [VV210], Animal and in vitro Models for Pharmaceuticals [VV450], traditional Chinese medicines, herbal drugs, pharmacology, coronavirus disease 2019, antiviral properties, genes, proteins, protein kinases, enzymes, interleukin 6, fever, signal transduction, phytosterols, atherosclerosis, pathogens, formononetin, plant extracts, Severe acute respiratory syndrome coronavirus 2, Human herpesvirus 5, Severe acute respiratory syndrome-related coronavirus, Betacoronavirus, Coronavirinae, Coronaviridae, Nidovirales, positive-sense ssRNA Viruses, ssRNA Viruses, RNA Viruses, viruses, Cytomegalovirus, Betaherpesvirinae, Herpesviridae, Herpesvirales, dsDNA Viruses, DNA Viruses, herbal medicines, SARS-CoV-2, anti-viral properties, pyrexia, arteriosclerosis, Human cytomegalovirus
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Collection:
Databases of international organizations
Database:
CAB Abstracts
Type of study:
Experimental Studies
Language:
Chinese
Journal:
Northwest Pharmaceutical Journal
Year:
2022
Document Type:
Article
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