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Chloroquine against malaria, cancers and viral diseases.
Zhou, Wenmin; Wang, Hui; Yang, Yuqi; Chen, Zhe-Sheng; Zou, Chang; Zhang, Jianye.
  • Zhou W; Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, PR China.
  • Wang H; Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, PR China; Guangzhou Institute of Pediatrics/Guangzhou Women and
  • Yang Y; College of Pharmacy and Health Sciences, St John's University, Queens, New York, NY 11439, USA.
  • Chen ZS; College of Pharmacy and Health Sciences, St John's University, Queens, New York, NY 11439, USA. Electronic address: chenz@stjohns.edu.
  • Zou C; The Second Clinical Medical College of Jinan University, Shenzhen, 518020, PR China. Electronic address: zou.chang@szhospital.com.
  • Zhang J; Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, PR China; Guangzhou Institute of Pediatrics/Guangzhou Women and
Drug Discov Today ; 2020 Sep 16.
Article in English | MEDLINE | ID: covidwho-2288973
ABSTRACT
Quinoline (QN) derivatives are often used for the prophylaxis and treatment of malaria. Chloroquine (CQ), a protonated, weakly basic drug, exerts its antimalarial effect mainly by increasing pH and accumulating in the food vacuole of the parasites. Repurposing CQ is an emerging strategy for new indications. Given the inhibition of autophagy and its immunomodulatory action, CQ shows positive efficacy against cancer and viral diseases, including Coronavirus 2019 (COVID-19). Here, we review the underlying mechanisms behind the antimalarial, anticancer and antiviral effects of CQ. We also discuss the clinical evidence for the use of CQ and hydroxychloroquine (HCQ) against COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal subject: Pharmacology / Drug Therapy Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal subject: Pharmacology / Drug Therapy Year: 2020 Document Type: Article