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Long-term effects of Pfizer-BioNTech COVID-19 vaccinations on platelets.
Zhou, Yuqi; Nishikawa, Masako; Kanno, Hiroshi; Yang, Ruoxi; Ibayashi, Yuma; Xiao, Ting-Hui; Peterson, Walker; Herbig, Maik; Nitta, Nao; Miyata, Shigeki; Kanthi, Yogendra; Rohde, Gustavo K; Moriya, Kyoji; Yatomi, Yutaka; Goda, Keisuke.
  • Zhou Y; Department of Chemistry, The University of Tokyo, Tokyo, Japan.
  • Nishikawa M; Department of Clinical Laboratory, The University of Tokyo Hospital, Tokyo, Japan.
  • Kanno H; Department of Chemistry, The University of Tokyo, Tokyo, Japan.
  • Yang R; Department of Chemistry, The University of Tokyo, Tokyo, Japan.
  • Ibayashi Y; Department of Chemistry, The University of Tokyo, Tokyo, Japan.
  • Xiao TH; Department of Chemistry, The University of Tokyo, Tokyo, Japan.
  • Peterson W; Department of Chemistry, The University of Tokyo, Tokyo, Japan.
  • Herbig M; Department of Chemistry, The University of Tokyo, Tokyo, Japan.
  • Nitta N; CYBO, Inc, Tokyo, Japan.
  • Miyata S; Research and Development Department, Central Blood Institute, Japanese Red Cross Society, Tokyo, Japan.
  • Kanthi Y; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
  • Rohde GK; Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA.
  • Moriya K; Department of Electrical and Computer Engineering, University of Virginia, Charlottesville, Virginia, USA.
  • Yatomi Y; Department of Infection Control and Prevention, The University of Tokyo Hospital, Tokyo, Japan.
  • Goda K; Department of Infectious Diseases, The University of Tokyo Hospital, Tokyo, Japan.
Cytometry A ; 2022 Aug 08.
Article in English | MEDLINE | ID: covidwho-20245395
ABSTRACT
There is a global concern about the safety of COVID-19 vaccines associated with platelet function. However, their long-term effects on overall platelet activity remain poorly understood. Here we address this problem by image-based single-cell profiling and temporal monitoring of circulating platelet aggregates in the blood of healthy human subjects, before and after they received multiple Pfizer-BioNTech (BNT162b2) vaccine doses over a time span of nearly 1 year. Results show no significant or persisting platelet aggregation trends following the vaccine doses, indicating that any effects of vaccinations on platelet turnover, platelet activation, platelet aggregation, and platelet-leukocyte interaction was insignificant.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies Topics: Long Covid / Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: Cyto.a.24677

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies Topics: Long Covid / Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: Cyto.a.24677