The interplay of cells, polymers, and vascularization in three-dimensional lung models and their applications in COVID-19 research and therapy.
Stem Cell Res Ther
; 14(1): 114, 2023 04 28.
Article
in English
| MEDLINE | ID: covidwho-2290740
ABSTRACT
Millions of people have been affected ever since the emergence of the corona virus disease of 2019 (COVID-19) outbreak, leading to an urgent need for antiviral drug and vaccine development. Current experimentation on traditional two-dimensional culture (2D) fails to accurately mimic the in vivo microenvironment for the disease, while in vivo animal model testing does not faithfully replicate human COVID-19 infection. Human-based three-dimensional (3D) cell culture models such as spheroids, organoids, and organ-on-a-chip present a promising solution to these challenges. In this report, we review the recent 3D in vitro lung models used in COVID-19 infection and drug screening studies and highlight the most common types of natural and synthetic polymers used to generate 3D lung models.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Polymers
/
COVID-19
Topics:
Vaccines
Limits:
Animals
/
Humans
Language:
English
Journal:
Stem Cell Res Ther
Year:
2023
Document Type:
Article
Affiliation country:
S13287-023-03341-4
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