Combined peripheral and central nervous system demyelination post-COVID-19 vaccination: A case report
Neuroimmunology Reports
; 2 (no pagination), 2022.
Article
in English
| EMBASE | ID: covidwho-2291036
ABSTRACT
Background:
During the era of the Coronavirus disease 2019 (COVID-19) pandemic, various neurological syndromes were reported during or after the infection. Fortunately, efforts were made to successfully develop various vaccines with high efficacy and safety. Despite the promising results of those vaccines, they are too novel to be fully understood. Here we are shedding light on a neurological case presentation that may be attributed to one of the COVID-19 vaccines. Case presentation A 23-year-old male patient with no prior comorbidities presented with quadriparesis and numbness that were clinically and electrophysiologically consistent with Guillain-Barre Syndrome (GBS). The condition started 10 days after the first dose of the AstraZeneca vaccine. Moreover, MRI of the brain and spinal cord has shown evidence of non-specific central demyelination. Despite the radiological finding, the patient is not fulfilling the diagnosis of a known demyelination disorder and the lesions regressed on follow-up. Since no better explanation or trigger could be found, a post-vaccination immune-mediated reaction was considered. Conclusion(s) We still cannot assume the certainty of the causality association between the vaccine and the neurological presentation. Meanwhile, we suggest vigilance for cases of GBS or myelitis following vaccination for Covid-19 and that post-vaccination surveillance programs ensure a statistically significant tool to prove or dispsrove the causality.Copyright © 2022 The Authors
AstraZeneca vaccine; Central demyelination; COVID-19 vaccine; COVID-19 vaccine adverse events; Guillain-barre syndrome (GBS); adult; article; case report; cerebrospinal fluid analysis; clinical article; clinical feature; computer assisted tomography; coronavirus disease 2019/dt [Drug Therapy]; coronavirus disease 2019/pc [Prevention]; demyelination/dt [Drug Therapy]; demyelination/si [Side Effect]; drug effect; drug safety; fluid-attenuated inversion recovery imaging; follow up; Guillain Barre syndrome/di [Diagnosis]; human; infection prevention; male; neuroimaging; paresthesia/co [Complication]; physiotherapy; polymerase chain reaction; quadriplegia/co [Complication]; vaccination; weakness/th [Therapy]; young adult; prednisolone/dt [Drug Therapy]; vaxzevria/ae [Adverse Drug Reaction]; vaxzevria/dt [Drug Therapy]
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Case report
Topics:
Long Covid
/
Vaccines
Language:
English
Journal:
Neuroimmunology Reports
Year:
2022
Document Type:
Article
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