Mutations of SARS-CoV-2 and their impact on disease diagnosis and severity
Informatics in medicine unlocked
; 2023.
Article
in English
| EuropePMC | ID: covidwho-2291100
ABSTRACT
Numerous variations of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), including D614G, B.1.1.7 (United Kingdom), B.1.1.28 (Brazil P1, P2), CAL.20C (Southern California), B.1.351 (South Africa), B.1.617 (B.1.617.1 Kappa & Delta B.1.617.2) and B.1.1.529, have been reported worldwide. The receptor-binding domain (RBD) of the spike (S) protein is involved in virus-cell binding, where virus-neutralizing antibodies (NAbs) react. Novel variants in the S-protein could maximize viral affinity for the human angiotensin-converting enzyme 2 (ACE2) receptor and increase virus transmission. Molecular detection with false-negative results may refer to mutations in the part of the virus's genome used for virus diagnosis. Furthermore, these changes in S-protein structure alter the neutralizing ability of NAbs, resulting in a reduction in vaccine efficiency. Further information is needed to evaluate how new mutations may affect vaccine efficacy.
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Collection:
Databases of international organizations
Database:
EuropePMC
Type of study:
Experimental Studies
/
Prognostic study
Language:
English
Journal:
Informatics in medicine unlocked
Year:
2023
Document Type:
Article
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