COVID-19 and androgenic status: testosterone or dihydrotestosterone have a pivotal role?
Journal of Men's Health
; 19(1):33-42, 2023.
Article
in English
| EMBASE | ID: covidwho-2291492
ABSTRACT
The aim of our study is analysis of the androgenic status including testosterone (T) and dihydrotestosterone (DHT) in men hospitalized with coronavirus disease 2019 (COVID-19) and them relationship with the course of the disease. This is a monocentric prospective study performed on 125 male patients hospitalized for COVID-19. We conducted hematological examination, blood biochemical profile, hemostasis analysis and hormonal examination (T and DHT levels) lung and chest computed tomography and also assessed outcomes of hospitalization. Low DHT serum level was found only in 18 patients (14.4%). Subjects with low DHT were significantly older compare to subjects with normal DHT. At the same time in patients with normal DHT white blood cells (WBC) count, neutrophils at admission were higher than in patients with low DHT. No correlation was observed between T and DHT serum blood levels. C-reactive protein (CRP) has a weak positive correlation of DHT serum blood concentration (r = 0.22;p = 0.016). The inverse pattern was obtained for T serum blood concentration (r = -0.285;p = 0.001). After divided all males according to T concentrations we conducted next correlation analysis for DHT and CRP in two different groups with normal T levels and with low T levels. We found that in males with normal T DHT levels are not correlated with CRP (r = 0.095;p = 0.462). However, in males with low T DHT and CRP had weak positive correlation with r = 0.317 (p = 0.012). Higher DHT concentrations are associated with higher CRP levels, however correlation is weak and in patients with normal T is absent, that may indicate anti-inflammatory effect of T and possible proinflammatory effect of DHT.Copyright © 2023 The Author(s).
covid-19; Dihydrotestosterone; Testosterone; adult; aged; antiinflammatory activity; article; blood analysis; blood chemistry; clinical assessment; clinical outcome; computer assisted tomography; controlled study; coronavirus disease 2019; correlation analysis; digital imaging and communications in medicine; disease course; hemostasis; hormone blood level; hospital patient; hospitalization; human; inflammation; leukocyte count; lung; lung infiltrate; major clinical study; male; neutrophil count; outcome assessment; prospective study; quantitative analysis; sex difference; testosterone blood level; thorax; androstanolone/ec [Endogenous Compound]; biological marker/ec [Endogenous Compound]; C reactive protein/ec [Endogenous Compound]; testosterone/ec [Endogenous Compound]; CT scanner; data analysis software; hematology analyzer; hemostasis testing system; immunoassay analyzer; radiology information processing system software; testosterone test kit; au480; Botkin.AI; Multivox; STA-compact; Syngo.via Version VAB; xn-2000
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Language:
English
Journal:
Journal of Men's Health
Year:
2023
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS