Probing different paradigms of morphine withdrawal on sleep behavior in male and female C57BL/6J mice.
Behav Brain Res
; 448: 114441, 2023 06 25.
Article
in English
| MEDLINE | ID: covidwho-2292068
ABSTRACT
Opioid misuse has dramatically increased over the last few decades resulting in many people suffering from opioid use disorder (OUD). The prevalence of opioid overdose has been driven by the development of new synthetic opioids, increased availability of prescription opioids, and more recently, the COVID-19 pandemic. Coinciding with increases in exposure to opioids, the United States has also observed increases in multiple Narcan (naloxone) administrations as a life-saving measures for respiratory depression, and, thus, consequently, naloxone-precipitated withdrawal. Sleep dysregulation is a main symptom of OUD and opioid withdrawal syndrome, and therefore, should be a key facet of animal models of OUD. Here we examine the effect of precipitated and spontaneous morphine withdrawal on sleep behaviors in C57BL/6 J mice. We find that morphine administration and withdrawal dysregulate sleep, but not equally across morphine exposure paradigms. Furthermore, many environmental triggers promote relapse to drug-seeking/taking behavior, and the stress of disrupted sleep may fall into that category. We find that sleep deprivation dysregulates sleep in mice that had previous opioid withdrawal experience. Our data suggest that the 3-day precipitated withdrawal paradigm has the most profound effects on opioid-induced sleep dysregulation and further validates the construct of this model for opioid dependence and OUD.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Substance Withdrawal Syndrome
/
COVID-19
/
Morphine Dependence
/
Opioid-Related Disorders
Type of study:
Observational study
/
Prognostic study
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
English
Journal:
Behav Brain Res
Year:
2023
Document Type:
Article
Affiliation country:
J.bbr.2023.114441
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