FAVIPIRAVIR IN THE TREATMENT OF MILD CORONAVIRUS INFECTION: RESULTS OF A MULTICENTER OPEN-LABEL, POST-REGISTRATION, NON-INTERVENTIONAL STUDY.
Eksperimental'naya i Klinicheskaya Farmakologiya
; 86(2):18-27, 2023.
Article
in Russian
| EMBASE | ID: covidwho-2292125
ABSTRACT
Clinical parameters characterizing the efficacy and safety of favipiravir were examined in a multicenter, non-interventional (before-and-after study design) trial in 264 patients with mild COVID-19. It is shown that on the background of 14-day therapy with favipiravir body temperature normalized, blood oxygen saturation improved, and the frequency of tachycardia detection reduced by 16% (p < 0.0001). A statistically significant decrease by 91,3% (p 0.0001) in the frequency of SARS-nCoV-2 RNA detection in the nasopharyngeal mucosa discharge was revealed. A decrease in the concentration of ferritin (by 69% compared to initial values), blood glucose (by 21%), creatinine (by 10%), C-reactive protein (by 36%) (p 0.0001), and D-dimer by 61% (p = 0.016) was noted. The results of the SF-36 health survey questionnaire revealed a significant (p 0.05) improvement in the quality of life in terms of physical functioning (by 35%), and role functioning associated with physical and emotional state by 107% and 160%, respectively. Analysis of the COV19-QoL questionnaire revealed a decrease by 24% in negative perception of the disease (p < 0,01). Among the identified adverse events, elevated level of ALT (in 39.47% of patients), hyperuricemia (in 28.95% of patients), and elevated AST (in 23.68% of patients) prevailed. All the adverse events occurred with mild or moderate severity. There were no lethal outcomes in the studied sample of patients. The analysis showed a satisfactory level of the tolerability of the treatment.Copyright © 2023 Izdatel'stvo Meditsina. All rights reserved.
covid-19; efficacy; favipiravir; safety; adult; alanine aminotransferase blood level; article; aspartate aminotransferase level; body temperature; controlled study; coronavirus disease 2019; drug efficacy; drug safety; drug therapy; drug tolerability; emotion; female; ferritin blood level; glucose blood level; human; human tissue; hyperuricemia; intervention study; major clinical study; male; mucosa; multicenter study; oxygen blood level; perception; quality of life; questionnaire; severe acute respiratory syndrome; Short Form 36; tachycardia; C reactive protein; creatinine; D dimer; endogenous compound; ferritin
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Experimental Studies
Language:
Russian
Journal:
Eksperimental'naya i Klinicheskaya Farmakologiya
Year:
2023
Document Type:
Article
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