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Association between soluble angiotensin-converting enzyme 2 in saliva and SARS-CoV-2 infection: a cross-sectional study.
Bru, Samuel; Brotons, Pedro; Jordan, Iolanda; Alsina, Laia; Henares, Desiree; Carballar, Reyes; de Sevilla, Mariona Fernandez; Barrabeig, Irene; Fumado, Victoria; Baro, Bàrbara; Martínez-Láinez, Joan Marc; Garcia-Garcia, Juan J; Bassat, Quique; Balaguer, Albert; Clotet, Josep; Launes, Cristian; Muñoz-Almagro, Carmen.
  • Bru S; Department of Basic Sciences, School of Medicine and Health Sciences, Universitat Internacional de Catalunya, Inmaculada, 22, 28029, Barcelona, Spain.
  • Brotons P; Institut de Recerca Sant Joan de Déu, Santa Rosa, 39-57, Esplugues de Llobregat, 08950, Barcelona, Spain. pedro.brotons@sjd.es.
  • Jordan I; Department of Medicine, School of Medicine and Health Sciences, Universitat Internacional de Catalunya, Inmaculada, 22, 28029, Barcelona, Spain. pedro.brotons@sjd.es.
  • Alsina L; Consorcio de Investigación Biomédica en Red de Epidemiología y Salud (CIBERESP), Instituto de Salud Carlos III, Monforte de Lemos 3-5, 28029, Madrid, Spain. pedro.brotons@sjd.es.
  • Henares D; Institut de Recerca Sant Joan de Déu, Santa Rosa, 39-57, Esplugues de Llobregat, 08950, Barcelona, Spain.
  • Carballar R; Consorcio de Investigación Biomédica en Red de Epidemiología y Salud (CIBERESP), Instituto de Salud Carlos III, Monforte de Lemos 3-5, 28029, Madrid, Spain.
  • de Sevilla MF; Paediatric Intensive Care Unit, Hospital Sant Joan de Déu, Sant Joan de Déu 2, 08950, Esplugues de Llobregat, Spain.
  • Barrabeig I; Institut de Recerca Sant Joan de Déu, Santa Rosa, 39-57, Esplugues de Llobregat, 08950, Barcelona, Spain.
  • Fumado V; Paediatric Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Sant Joan de Déu 2, 08950, Esplugues de Llobregat, Spain.
  • Baro B; Institut de Recerca Sant Joan de Déu, Santa Rosa, 39-57, Esplugues de Llobregat, 08950, Barcelona, Spain.
  • Martínez-Láinez JM; Consorcio de Investigación Biomédica en Red de Epidemiología y Salud (CIBERESP), Instituto de Salud Carlos III, Monforte de Lemos 3-5, 28029, Madrid, Spain.
  • Garcia-Garcia JJ; Department of Basic Sciences, School of Medicine and Health Sciences, Universitat Internacional de Catalunya, Inmaculada, 22, 28029, Barcelona, Spain.
  • Bassat Q; Institut de Recerca Sant Joan de Déu, Santa Rosa, 39-57, Esplugues de Llobregat, 08950, Barcelona, Spain.
  • Balaguer A; Paediatrics Department, Hospital Sant Joan de Déu, Sant Joan de Déu 2, 08950, Esplugues de Llobregat, Spain.
  • Clotet J; Consorcio de Investigación Biomédica en Red de Epidemiología y Salud (CIBERESP), Instituto de Salud Carlos III, Monforte de Lemos 3-5, 28029, Madrid, Spain.
  • Launes C; Agència de Salut Pública de Catalunya, Roc Boronat 81, 08005, Barcelona, Spain.
  • Muñoz-Almagro C; Infectious Diseases Department, Hospital Sant Joan de Déu, Sant Joan de Déu 2, 08950, Esplugues de Llobregat, Spain.
Sci Rep ; 13(1): 5985, 2023 04 12.
Article in English | MEDLINE | ID: covidwho-2292650
ABSTRACT
This study aimed to investigate the association between saliva soluble angiotensin-converting enzyme 2 (sACE2) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children and adults. We selected a convenience sample of adults with post-acute SARS-CoV-2 infection and their household children living in quarantined family households of the metropolitan Barcelona region (Spain) during the spring 2020 pandemic national lockdown. Participants were tested for saliva sACE2 quantification by western blot and nasopharyngeal SARS-CoV-2 RT-PCR detection. A total of 161 saliva samples [82 (50.9%) from children; 79 (49.1%) from females] yielded valid western blot and RT-PCR results. Saliva sACE2 was detected in 79 (96.3%) children and 76 (96.2%) convalescent adults. Twenty (24.4%) children and 20 (25.3%) convalescent adults were positive for SARS-CoV-2 in nasopharynx by RT-PCR. SARS-CoV-2 RT-PCR-negative children had a significantly higher mean proportional level of saliva sACE2 (0.540 × 10-3%) than RT-PCR-positive children (0.192 × 10-3%, p < 0.001) and convalescent adults (0.173 × 10-3%, p < 0.001). In conclusion, children negative for nasopharyngeal SARS-CoV-2 RT-PCR appear to exhibit a higher concentration of saliva sACE2 than SARS-CoV-2 RT-PCR-positive children and convalescent adults. Release of adequate levels of sACE2 in saliva could play a protective role against SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Observational study / Randomized controlled trials Topics: Long Covid Limits: Adult / Child / Female / Humans Language: English Journal: Sci Rep Year: 2023 Document Type: Article Affiliation country: S41598-023-31911-2

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Observational study / Randomized controlled trials Topics: Long Covid Limits: Adult / Child / Female / Humans Language: English Journal: Sci Rep Year: 2023 Document Type: Article Affiliation country: S41598-023-31911-2