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Neutralizing Antibody Responses After Severe Acute Respiratory Syndrome Coronavirus 2 BA.2 and BA.2.12.1 Infection Do Not Neutralize BA.4 and BA.5 and Can Be Blunted by Nirmatrelvir/Ritonavir Treatment.
Carlin, Aaron F; Clark, Alex E; Garretson, Aaron F; Bray, William; Porrachia, Magali; Santos, AsherLev T; Rana, Tariq M; Chaillon, Antoine; Smith, Davey M.
  • Carlin AF; School of Medicine, University of California San Diego, La Jolla, California, USA.
  • Clark AE; School of Medicine, University of California San Diego, La Jolla, California, USA.
  • Garretson AF; School of Medicine, University of California San Diego, La Jolla, California, USA.
  • Bray W; School of Medicine, University of California San Diego, La Jolla, California, USA.
  • Porrachia M; School of Medicine, University of California San Diego, La Jolla, California, USA.
  • Santos AT; Department of Public Health, College of Education, Health and Human Services, California State University San Marcos, San Marcos, California, USA.
  • Rana TM; School of Medicine, University of California San Diego, La Jolla, California, USA.
  • Chaillon A; School of Medicine, University of California San Diego, La Jolla, California, USA.
  • Smith DM; School of Medicine, University of California San Diego, La Jolla, California, USA.
Open Forum Infect Dis ; 10(4): ofad154, 2023 Apr.
Article in English | MEDLINE | ID: covidwho-2292925
ABSTRACT
The factors contributing to the rapid emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) BA.4 and BA.5 subvariants in populations that experienced recent surges of BA.2 and BA.2.12.1 infections are not understood. Neutralizing antibodies (NAbs) are likely to protect against severe disease if present in sufficient quantity. We found that after BA.2 or BA.2.12.1 infection, NAb responses were largely cross-neutralizing but were much less effective against BA.5. In addition, individuals who were infected and treated early with nirmatrelvir/ritonavir (Paxlovid) had lower NAb levels than untreated individuals.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Randomized controlled trials Language: English Journal: Open Forum Infect Dis Year: 2023 Document Type: Article Affiliation country: Ofid

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Randomized controlled trials Language: English Journal: Open Forum Infect Dis Year: 2023 Document Type: Article Affiliation country: Ofid