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Mycobacterium tuberculosis and SARS-CoV-2 co-infections: The knowns and unknowns.
Chiok, Kim R; Dhar, Neeraj; Banerjee, Arinjay.
  • Chiok KR; Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada.
  • Dhar N; Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada.
  • Banerjee A; Department of Biochemistry, Microbiology and Immunology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.
iScience ; 26(5): 106629, 2023 May 19.
Article in English | MEDLINE | ID: covidwho-2293397
ABSTRACT
Health impacts of Mycobacterium tuberculosis (Mtb) and SARS-CoV-2 co-infections are not fully understood. Both pathogens modulate host responses and induce immunopathology with extensive lung damage. With a quarter of the world's population harboring latent TB, exploring the relationship between SARS-CoV-2 infection and its effect on the transition of Mtb from latent to active form is paramount to control this pathogen. The effects of active Mtb infection on establishment and severity of COVID-19 are also unknown, despite the ability of TB to orchestrate profound long-lasting immunopathologies in the lungs. Absence of mechanistic studies and co-infection models hinder the development of effective interventions to reduce the health impacts of SARS-CoV-2 and Mtb co-infection. Here, we highlight dysregulated immune responses induced by SARS-CoV-2 and Mtb, their potential interplay, and implications for co-infection in the lungs. As both pathogens master immunomodulation, we discuss relevant converging and diverging immune-related pathways underlying SARS-CoV-2 and Mtb co-infections.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: IScience Year: 2023 Document Type: Article Affiliation country: J.isci.2023.106629

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: IScience Year: 2023 Document Type: Article Affiliation country: J.isci.2023.106629