Facile and scalable synthesis of baphicacanthin A by a two-pot procedure.
Nat Prod Res
; : 1-5, 2021 Dec 02.
Article
in English
| MEDLINE | ID: covidwho-2293741
ABSTRACT
Facile two-pot total synthesis of baphicacanthin A, a natural phenoxazinone alkaloid isolated from the roots of Baphicacanthus cusia which has been utilized as a traditional chinese medicine to effectively treat disease caused by coronavirus, has been developed from simple and commercially available starting materials. Catalytic aerobic oxidative cross-cyclocondensation of equimolar 2-aminophenol and 3-methoxy-2-hydroxylphenol in water was used to construct the key molecular skeleton 2-hydroxy-3H-phenoxazin-3-one. Gram scale synthesis was realized in 80% overall yield with practical convenience.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Randomized controlled trials
Topics:
Traditional medicine
Language:
English
Journal:
Nat Prod Res
Year:
2021
Document Type:
Article
Affiliation country:
14786419.2021.2011275
Similar
MEDLINE
...
LILACS
LIS