DISTRIBUTION OF POLYMORPHIC GENE VARIANTS ASSOCIATED WITH THE SEVERE COURSE OF COVID-19 IN THE SUBPOPULATION OF BASHKIRS

ABSTRACT

We have analyzed the distribution of alleles and genotypes of three polymorphic variants rs11385942 of the LZTFL1 gene, rs657152 of the AB0 gene, and rs2109069 of the DPP9 gene previously associated with COVID-19 in a sample of 80 presumably healthy individuals of the Permsky Bashkirs from the Permsky region of Russia, 48 representatives of the Burzyan region and 47 representatives of the Arkhangelsky district of the Republic of Bashkortostan of Russia. No statistically significant differences were shown between the Burzyan Bashkirs and the populations of Southern Siberia in the rs11385942 LZTFL1 locus, in contrast to the subpopulations of the Permsky and Arkhangelsky Bash-kirs. We also revealed statistically significant differences in the frequency of the minor allele, the rs11385942 LZTFL1 and rs657152 loci of the ABO gene between Burzyan Bashkirs and a mixed sample of Komi and Udmurts. In turn, the subpopulations of the Permsky and Arkhangelsky Bashkirs in the rs657152 locus of the ABO gene were statistically significantly different from the Tatars. © 2023, Lobachevsky State University of Nizhny Novgorod. All rights reserved.