Associations between brain gene expression perturbations implicated by COVID-19 and psychiatric disorders.
J Psychiatr Res
; 162: 79-87, 2023 06.
Article
in English
| MEDLINE | ID: covidwho-2295339
ABSTRACT
BACKGROUND:
Currently, there is increasing evidence from clinic, epidemiology, as well as neuroimaging, demonstrating neuropsychiatric abnormalities in COVID-19, however, whether there were associations between brain changes caused by COVID-19 and genetic susceptibility of psychiatric disorders was still unknown.METHODS:
In this study, we performed a meta-analysis to investigate these associations by combing single-cell RNA sequencing datasets of brain tissues of COVID-19 and genome-wide association study summary statistics of psychiatric disorders.RESULTS:
The analysis demonstrated that among ten psychiatric disorders, gene expression perturbations implicated by COVID-19 in excitatory neurons of choroid plexus were significantly associated with schizophrenia.CONCLUSIONS:
Our analysis might provide insights for the underlying mechanism of the psychiatric consequence of COVID-19.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
/
Mental Disorders
Type of study:
Reviews
Limits:
Humans
Language:
English
Journal:
J Psychiatr Res
Year:
2023
Document Type:
Article
Affiliation country:
J.jpsychires.2023.03.033
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