Liquid Chromatographic Approach for Analysis of Favipiravir–A Repurpose Drug for COVID-19
International Journal of Pharmaceutical Quality Assurance
; 14(1):16-20, 2023.
Article
in English
| Scopus | ID: covidwho-2295621
ABSTRACT
Favipiravir is a potential repurpose moiety to treat COVID-19 by depletion of virus load in infectious patients. To analyze and separate Favipiravir with remarkable efficiency, X-Bridge C8 column (150 x 4.6 mm, 5 µ) and a solvent phase of 0.1% TEA and acetonitrile (4060 v/v) with 1-mL/min flow rate were used. The eluted favipiravir and possible degradants were detected at 225 nm. Further, the process was validated by using ICH (Q2R1) guidelines to ensure the method's suitability in the pharmaceutical sector. The RT of Favipiravir was observed at 3.7 min with good linearity of 2 to 30 µg/mL. %RSD of both system and method precision was assessed in the series of 0.32 to 0.98. The mean percentage recovery of Favipiravir was in the range of 99.0–100.4%. The limit of detection (LoD) and limit of quantification (LoQ) were assessed to be 0.024 and 0.084 μg/mL for favipiravir. The outcomes confirmed that the projected approach was economical, insightful, simple and precise with better sensitivity. Investigation of Favipiravir in the incidence of a variety of stressed or forced degradation environments ensures stability indicating quality of the developed approach. © 2023, Dr. Yashwant Research Labs Pvt. Ltd.. All rights reserved.
Favipiravir; Forced degradation; Sensitivity; Stability indicating; X-Bridge C8 column; accuracy; Article; coronavirus disease 2019; drug solubility; drug stability; limit of detection; limit of quantitation; liquid chromatography; measurement accuracy; measurement precision; measurement repeatability; photodegradation; physical chemistry; process optimization; validation process
Full text:
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Collection:
Databases of international organizations
Database:
Scopus
Language:
English
Journal:
International Journal of Pharmaceutical Quality Assurance
Year:
2023
Document Type:
Article
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