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A platelet lipidomics signature in patients with COVID-19.
Goracci, Laura; Petito, Eleonora; Di Veroli, Alessandra; Falcinelli, Emanuela; Bencivenga, Caterina; Giglio, Elisa; Becattini, Cecilia; De Robertis, Edoardo; Vaudo, Gaetano; Gresele, Paolo.
  • Goracci L; Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy.
  • Petito E; Department of Medicine and Surgery, Section of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy.
  • Di Veroli A; Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy.
  • Falcinelli E; Department of Medicine and Surgery, Section of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy.
  • Bencivenga C; Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy.
  • Giglio E; Department of Medicine and Surgery, Section of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy.
  • Becattini C; Department of Medicine and Surgery, Section of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy.
  • De Robertis E; Division of Anaesthesia, Analgesia, and Intensive Care, University of Perugia, Perugia, Italy.
  • Vaudo G; Unit of Internal Medicine, Terni University Hospital, Terni, Italy.
  • Gresele P; Department of Medicine and Surgery, Section of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy.
Platelets ; 34(1): 2200847, 2023 Dec.
Article in English | MEDLINE | ID: covidwho-2295721
ABSTRACT
Ischemic cardiovascular and venous thromboembolic events are a frequent cause of death in severe COVID-19 patients. Platelet activation plays a key role in these complications, however platelet lipidomics have not been studied yet. The aim of our pilot investigation was to perform a preliminary study of platelet lipidomics in COVID-19 patients compared to healthy subjects. Lipid extraction and identification of ultrapurified platelets from eight hospitalized COVID-19 patients and eight age- and sex-matched healthy controls showed a lipidomic pattern almost completely separating COVID-19 patients from healthy controls. In particular, a significant decrease of ether phospholipids and increased levels of ganglioside GM3 were observed in platelets from COVID-19 patients. In conclusion, our study shows for the first time that platelets from COVID-19 patients display a different lipidomics signature distinguishing them from healthy controls, and suggests that altered platelet lipid metabolism may play a role in viral spreading and in the thrombotic complications of COVID-19.
What is the context? Besides respiratory system involvement, venous thromboembolism is a severe complication of COVID-19, largely due to the strong derangement of hemostasis, with platelets playing a central role.Great attention has recently been devoted to lipid alterations in COVID-19, both because viruses by reprogramming cellular lipid metabolism remodel lipid membranes to fuel their replication, and because the COVID-19-associated cytokine storm may affect cell/plasma lipidomic signatures.Lipidomics studies in COVID-19 patients have been performed mainly in plasma and serum.To the best of our knowledge, platelet lipidomics have not been examined despite the central role played by platelets in COVID-19 complications.What is the aim of the study?The aim of our pilot study was to preliminarily explore whether platelet lipidomics is altered in COVID-19 patients compared to age- and sex-matched healthy subjects, analyzing lipidomic profile of ultrapurified platelets.What are the results of our study? Our study shows for the first time that platelets from COVID-19 patients display a different lipidomics signature distinguishing them from healthy controls.Ether phospholipids and, intriguingly, two phytoceramides were lower, while ganglioside GM3 was higher in COVID-19 samples compared to healthy controls.What is the impact?Despite the small number of COVID-19 patients enrolled, recognized as a limitation of our study, we show, for the first time, that platelets from COVID-19 patients present a different lipidomics signature and suggest that altered platelet lipid metabolism may play a significant role in viral spreading and in the thrombotic complications of COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombosis / COVID-19 Limits: Humans Language: English Journal: Platelets Journal subject: Hematology Year: 2023 Document Type: Article Affiliation country: 09537104.2023.2200847

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombosis / COVID-19 Limits: Humans Language: English Journal: Platelets Journal subject: Hematology Year: 2023 Document Type: Article Affiliation country: 09537104.2023.2200847