Effectiveness and Duration of Protection of a Fourth Dose of COVID-19 mRNA Vaccine among Long-Term Care Residents in Ontario, Canada.

Grewal, Ramandip; Nguyen, Lena; Buchan, Sarah A; Wilson, Sarah E; Costa, Andrew P; Kwong, Jeffrey C

Grewal, Ramandip; Nguyen, Lena; Buchan, Sarah A; Wilson, Sarah E; Costa, Andrew P; Kwong, Jeffrey C.

Grewal R; Public Health Ontario, Toronto, Ontario, M5G 1M1, Canada.
Nguyen L; ICES, Toronto, Ontario, M4N 3M5, Canada.
Buchan SA; Public Health Ontario, Toronto, Ontario, M5G 1M1, Canada.
Wilson SE; ICES, Toronto, Ontario, M4N 3M5, Canada.
Costa AP; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, M5T 3M7, Canada.
Kwong JC; Centre for Vaccine Preventable Diseases, University of Toronto, Toronto, Ontario, M5T 3M7, Canada.

J Infect Dis ; 2022 Dec 03.

Article in English | MEDLINE | ID: covidwho-2295821

ABSTRACT

ABSTRACT

We estimated the effectiveness of a fourth dose of mRNA COVID-19 vaccine against Omicron infections and severe outcomes over time among long-term care residents in Ontario, Canada. Fourth doses provide additional protection against Omicron-related outcomes, but the protection wanes over time, with more waning seen against infection than severe outcomes.

Keywords

COVID-19; Duration of Protection; Fourth Doses; Long-Term Care Residents; Marginal effectiveness; Vaccine effectiveness

Fulltext

XML

PubMed Links

Search on Google

Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies Topics: Long Covid / Vaccines / Variants Language: English Year: 2022 Document Type: Article Affiliation country: Infdis

Similar

MEDLINE

LILACS

LIS

Fulltext

XML

PubMed Links

Search on Google