Memory T cell responses in seronegative older adults following SARS-CoV-2 vaccination
Clinical Immunology Communications
; 2:154-158, 2022.
Article
in English
| EMBASE | ID: covidwho-2296042
ABSTRACT
Generating memory T cell responses besides humoral immune responses is essential when it comes to the efficacy of a vaccine. In this study, the presence of memory T cell responses after aluminum-adjuvanted inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac) in seronegative and seropositive elderly individuals were examined. CD4+ and CD8+ memory T cell proliferation and IFN-gamma production capacities were evaluated. Additionally, clinical frailty scale (CFS) and FRAIL scales of the individuals were scored. CD4+ memory T cell responses more prominent than CD8+ memory T cells. In seronegative individuals, 80% of them had memory CD4+ and IFN-gamma, whereas 50% of them had memory CD4+ and all of them had IFN-gamma responses. Additionally, 40% of seronegative patients and 50% of seropositive patients had memory CD8+ responses. To sum up, humoral immune responses are not associated with memory T cell responses, and in seronegative individuals, memory T cell responses can be detected.Copyright © 2022
covid-19; Memory T cell responses; Vaccine; aged; aging; antibody response; article; CD4+ T lymphocyte; CD8+ T lymphocyte; cellular immunity; Clinical Frailty Scale; controlled study; coronavirus disease 2019/dt [Drug Therapy]; coronavirus disease 2019/pc [Prevention]; cytokine production; cytokine release; female; human; humoral immunity; immune response; immunoglobulin blood level; lymphocyte proliferation; male; memory T lymphocyte; vaccination; coronavac/dt [Drug Therapy]; coronavac/pv [Special Situation for Pharmacovigilance]; gamma interferon/ec [Endogenous Compound]; immunoglobulin G antibody/ec [Endogenous Compound]
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Topics:
Vaccines
Language:
English
Journal:
Clinical Immunology Communications
Year:
2022
Document Type:
Article
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