Predictive value of fasting blood glucose and TG/HDL-C ratio in non-diabetic patients with COVID-19
Journal of Modern Laboratory Medicine
; 37(5):9-13, 2022.
Article
in Chinese
| GIM | ID: covidwho-2296134
ABSTRACT
Objective:
To investigate the predictive values of fasting blood glucose and triglyceride/high-density lipoprotein cholesterol ratio (TG/HDL-C) in non-diabetic patients with COVID-19.Methods:
A total of 39 non-diabetic patients with COVID-19 admitted to the Fourth Hospital of Xi'an from December 2021 to January 2022 were included. And 34 health examination subjects from the Second Affiliated Hospital of Xi'an Jiaotong University were matched as health control according to their propensity score. The clinical characteristics and laboratory test results between groups were compared, and the predictive value of fasting glucose and TG/HDL-C in non-diabetic COVID-19 patients was analyzed by logistic regression and receiver operating curve (ROC).Results:
COVID-19 patients were either mild (30 cases) or common type (9 cases) with mild symptoms and good clinical prognosis. The median age was 29.0 (20.0, 49.0) years, 24 (61.5%) were males. Fasting blood glucose (4.30+or-0.47 mmol/L) and HDL-C [1.07 (0.86, 1.30) mmol/L] levels in COVID-19 patients were significantly lower than healthy controls [5.15+or-0.70 mmol/L, 2.24 (1.77, 3.05) mmol/L], the differences were statistically significant (t=6.277, P < 0.001;Z=6.026, P < 0.001). However, low density lipoprotein cholesterol (LDL-C) [2.40 (1.81, 2.91) mmol/L] and TG/HDL-C [0.91 (0.54, 1.52)] in COVID-19 patients were significantly increased compared to healthy controls [1.11 (0.99, 1.30) mmol/L, 0.54 (0.33, 0.90)], and the differences were statistically significant (Z=-6.271, -2.801, all P < 0.005). Logistic regression analysis showed that fasting blood glucose on admission could be an independent protective factor (OR0.020, 95% CI 0.003 ~ 0.150) and elevated TG/HDL-C be a risk factor (OR4.802, 95% CI 1.249 ~ 18.460) for COVID-19 infection among non-diabetic populations. The ROC curve showed that fasting blood glucose and TG/HDL-C were good at predicting the risk of COVID-19, and the area under the curve (AUC) were 0.871 and 0.708, respectively, and was 0.895 when combined.Conclusion:
Decreased fasting blood glucose and elevated TG/HDL-C would be risk factors for COVID-19 infection in the non-diabetic population, and both have good predictive value for the incidence of COVID-19.
blood sugar; coronavirus disease 2019; high density lipoprotein; human diseases; pandemics; patients; predictive value; risk factors; triacylglycerols; viral diseases; man; Severe acute respiratory syndrome coronavirus 2; China; Shaanxi; APEC countries; East Asia; Asia; high Human Development Index countries; upper-middle income countries; Homo; Hominidae; primates; mammals; vertebrates; Chordata; animals; eukaryotes; Severe acute respiratory syndrome-related coronavirus; Betacoronavirus; Coronavirinae; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; viruses; North Western China; blood glucose; glucose in blood; People's Republic of China; SARS-CoV-2; Shensi; triglycerides; viral infections
Full text:
Available
Collection:
Databases of international organizations
Database:
GIM
Type of study:
Prognostic study
Language:
Chinese
Journal:
Journal of Modern Laboratory Medicine
Year:
2022
Document Type:
Article
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