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Molecular Understanding of ACE-2 and HLA-Conferred Differential Susceptibility to COVID-19: Host-Directed Insights Opening New Windows in COVID-19 Therapeutics.
Haq, Ihtisham Ul; Krukiewicz, Katarzyna; Tayyab, Hamnah; Khan, Imran; Khan, Mehtab; Yahya, Galal; Cavalu, Simona.
  • Haq IU; Department of Physical Chemistry and Technology of Polymers, Silesian University of Technology, 44-100 Gliwice, Poland.
  • Krukiewicz K; Department of Biosciences, COMSATS University Islamabad (CUI), Islamabad 44000, Pakistan.
  • Tayyab H; Joint Doctoral School, Silesian University of Technology, 44-100 Gliwice, Poland.
  • Khan I; Department of Physical Chemistry and Technology of Polymers, Silesian University of Technology, 44-100 Gliwice, Poland.
  • Khan M; Centre for Organic and Nanohybrid Electronics, Silesian University of Technology, 44-100 Gliwice, Poland.
  • Yahya G; Department of Internal Medicine, King Edward Medical College, Lahore 54000, Pakistan.
  • Cavalu S; Department of Molecular Signal Processing, Leibniz Institute of Plant Biochemistry, 06120 Halle, Germany.
J Clin Med ; 12(7)2023 Apr 01.
Article in English | MEDLINE | ID: covidwho-2296169
ABSTRACT
The genetic variants of HLAs (human leukocyte antigens) play a crucial role in the virus-host interaction and pathology of COVID-19. The genetic variants of HLAs not only influence T cell immune responses but also B cell immune responses by presenting a variety of peptide fragments of invading pathogens. Peptide cocktail vaccines produced by using various conserved HLA-A2 epitopes provoke substantial specific CD8+ T cell responses in experimental animals. The HLA profiles vary among individuals and trigger different T cell-mediated immune responses in COVID-19 infections. Those with HLA-C*01 and HLA-B*44 are highly susceptible to the disease. However, HLA-A*0201, HLA-DR*0301, and HLA-Cw*1502 alleles show resistance to SARS infection. Understanding the genetic association of HLA with COVID-19 susceptibility and severity is important because it can help in studying the transmission of COVID-19 and its physiopathogenesis. The HLA-C*01 and B*44 allele pathways can be studied to gain insight into disease transmission and physiopathogenesis. Therefore, integrating HLA testing is suggested in the ongoing pandemic, which will help in the rapid identification of highly susceptible populations worldwide and possibly acclimate vaccine development. Therefore, understanding the correlation between HLA and SARS-CoV-2 is critical in opening new insights into COVID-19 therapeutics, based on previous studies conducted.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Vaccines / Variants Language: English Year: 2023 Document Type: Article Affiliation country: Jcm12072645

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Vaccines / Variants Language: English Year: 2023 Document Type: Article Affiliation country: Jcm12072645