Curcumin as a natural systemic disease modulator

ABSTRACT

In the prevention and treatment of various diseases, a variety of preparations based on medicinal plants are now generally acknowledged and well-documented. The main advantages of traditional medicine in underdeveloped nations are safety and affordability. As diferuloylmethane, curcumin is a naturally occurring polyphenol that is mostly produced in the rhizomes of plant roots. Curcumin has a long history of usage in conventional medicine, although its therapeutic effects and health advantages are still little understood. The therapeutic benefits of curcumin include the treatment of malignancies, neurodegenerative, ocular, and COVID diseases as well as inflammatory and digestive disorders, rheumatic and skin issues, and tumors. Apoptosis-related genes, cytokines, enzymes, and other targets have all been found in certain studies to be modulated by curcumin. Furthermore, little is known about the biological mechanisms that underlie these activities. We will examine some of the known molecular targets and biological processes of curcumin in this chapter. The processes through which curcumin functions in neuroprotection and/or mental health disorders will be covered in this chapter. We will also talk about curcumin's protective role in how bone may impact neurological function. © 2023 Nova Science Publishers, Inc.