Human immune and gut microbial parameters associated with inter-individual variations in COVID-19 mRNA vaccine-induced immunity.
Commun Biol
; 6(1): 368, 2023 04 20.
Article
in English
| MEDLINE | ID: covidwho-2296483
ABSTRACT
COVID-19 mRNA vaccines induce protective adaptive immunity against SARS-CoV-2 in most individuals, but there is wide variation in levels of vaccine-induced antibody and T-cell responses. However, the mechanisms underlying this inter-individual variation remain unclear. Here, using a systems biology approach based on multi-omics analyses of human blood and stool samples, we identified several factors that are associated with COVID-19 vaccine-induced adaptive immune responses. BNT162b2-induced T cell response is positively associated with late monocyte responses and inversely associated with baseline mRNA expression of activation protein 1 (AP-1) transcription factors. Interestingly, the gut microbial fucose/rhamnose degradation pathway is positively correlated with mRNA expression of AP-1, as well as a gene encoding an enzyme producing prostaglandin E2 (PGE2), which promotes AP-1 expression, and inversely correlated with BNT162b2-induced T-cell responses. These results suggest that baseline AP-1 expression, which is affected by commensal microbial activity, is a negative correlate of BNT162b2-induced T-cell responses.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Gastrointestinal Microbiome
/
COVID-19
Type of study:
Prognostic study
/
Risk_factors_studies
Topics:
Vaccines
Limits:
Humans
Language:
English
Journal:
Commun Biol
Year:
2023
Document Type:
Article
Affiliation country:
S42003-023-04755-9
Similar
MEDLINE
...
LILACS
LIS