Your browser doesn't support javascript.
Application of weighted gene co-expression network and immune infiltration for explorations of key genes in the brain of elderly COVID-19 patients.
Huang, Lixia; Qin, Wei; Guo, Zirui; Li, Xiaoyu; Li, Fajiu; Wang, Xiang.
  • Huang L; Department of Immunology, School of Medicine, Jianghan University, Wuhan, China.
  • Qin W; Tianyuan Translational Medicine R&D Team, School of Medicine, Jianghan University, Wuhan, China.
  • Guo Z; Department of Immunology, School of Medicine, Jianghan University, Wuhan, China.
  • Li X; Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Jianghan University, Wuhan, China.
  • Li F; Institution of Pulmonary Vascular Disease, Jianghan University, Wuhan, China.
  • Wang X; Department of Materials (D-MATL), ETH Zurich, Zurich, Switzerland.
Front Immunol ; 14: 1157179, 2023.
Article in English | MEDLINE | ID: covidwho-2296687
ABSTRACT

Introduction:

Although many studies have demonstrated the existing neurological symptoms in COVID-19 patients, the mechanisms are not clear until now. This study aimed to figure out the critical molecular and immune infiltration situations in the brain of elderly COVID-19 patients.

Methods:

GSE188847 was used for the differential analysis, WGCNA, and immune infiltration analysis. We also performed GO, KEGG, GSEA, and GSVA for the enrich analysis.

Results:

266 DEGs, obtained from the brain samples of COVID-19 and non-COVID-19 patients whose ages were over 70 years old, were identified. GO and KEGG analysis revealed the enrichment in synapse and neuroactive ligand-receptor interaction in COVID-19 patients. Further analysis found that asthma and immune system signal pathways were significant changes based on GSEA and GSVA. Immune infiltration analysis demonstrated the imbalance of CD8+ T cells, neutrophils, and HLA. The MEpurple module genes were the most significantly different relative to COVID-19. Finally, RPS29, S100A10, and TIMP1 were the critical genes attributed to the progress of brain damage.

Conclusion:

RPS29, S100A10, and TIMP1 were the critical genes in the brain pathology of COVID-19 in elderly patients. Our research has revealed a new mechanism and a potential therapeutic target.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Asthma / Brain Injuries / COVID-19 Limits: Aged / Humans Language: English Journal: Front Immunol Year: 2023 Document Type: Article Affiliation country: Fimmu.2023.1157179

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Asthma / Brain Injuries / COVID-19 Limits: Aged / Humans Language: English Journal: Front Immunol Year: 2023 Document Type: Article Affiliation country: Fimmu.2023.1157179