Early detection of recurrent HPV+ hypopharyngeal squamous cell carcinoma by circulating tumor DNA
Otolaryngology Case Reports
; 27 (no pagination), 2023.
Article
in English
| EMBASE | ID: covidwho-2297495
ABSTRACT
Circulating tumor DNA is a liquid biomarker that offers a highly specific method to assess HPV-associated tumor burden via a blood draw. It has the potential for many clinical applications in cancer care, including prognostication, monitoring treatment response, and surveillance for disease recurrence. In this case report, we present a case of recurrent HPV-associated hypopharyngeal squamous cell carcinoma first detected by circulating tumor HPV DNA that demonstrates the role of circulating tumor HPV DNA tests in posttreatment surveillance and the utility of HPV testing in all HPV-mediated tumors, regardless of subsite.Copyright © 2023 Elsevier Inc.
Circulating tumor DNA; Head and neck cancer; Human papillomavirus; aged; article; cancer recurrence; cancer staging; case report; chemoradiotherapy; clinical article; coronavirus disease 2019; cytopathology; direct laryngoscopy; disease exacerbation; droplet digital polymerase chain reaction; dysphagia; dyspnea; early cancer diagnosis; fine needle aspiration biopsy; follow up; free tissue graft; health care utilization; hospital; human; Human papillomavirus type 16; hypopharynx squamous cell carcinoma/di [Diagnosis]; hypopharynx squamous cell carcinoma/dt [Drug Therapy]; hypopharynx squamous cell carcinoma/rt [Radiotherapy]; hypopharynx squamous cell carcinoma/su [Surgery]; inflammation; liquid; male; medical history; monitoring; mucosa; neck dissection; nonhuman; positron emission tomography; positron emission tomography-computed tomography; reconstructive surgery; recurrent disease/di [Diagnosis]; recurrent disease/su [Surgery]; swelling; thyroid cartilage; total laryngectomy; treatment response; antibiotic agent/pv [Special Situation for Pharmacovigilance]; circulating tumor DNA/ec [Endogenous Compound]; cisplatin/cb [Drug Combination]; cisplatin/dt [Drug Therapy]; cisplatin/pv [Special Situation for Pharmacovigilance]; docetaxel/cb [Drug Combination]; docetaxel/dt [Drug Therapy]; docetaxel/pv [Special Situation for Pharmacovigilance]; fluorouracil/cb [Drug Combination]; fluorouracil/dt [Drug Therapy]; fluorouracil/pv [Special Situation for Pharmacovigilance]; Human papillomavirus DNA test
Full text:
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Collection:
Databases of international organizations
Database:
EMBASE
Language:
English
Journal:
Otolaryngology Case Reports
Year:
2023
Document Type:
Article
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