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Delayed Diagnosis and Prognostic Impact of Breast Cancer During the COVID-19 Pandemic.
Adachi, Kayo; Kimura, Fuyo; Takahashi, Hideto; Kaise, Hiroshi; Yamada, Kimito; Ueno, Ei; Kawate, Takahiko; Miyahara, Kana; Ueda, Ai; Sato, Saeko; Asaoka, Mariko; Okazaki, Miki; Uenaka, Natsuki; Orimoto, Kyoko; Wu, Rongrong; Koyama, Yoichi; Ishikawa, Takashi.
  • Adachi K; Tokyo Medical University Hospital, Tokyo, Japan. Electronic address: k-adachi@tokyo-med.ac.jp.
  • Kimura F; Tokyo Medical University Hospital, Tokyo, Japan; The Second Kawasaki Saiwai Clinic, Kanagawa, Japan. Electronic address: f-kimura@saiwaihp.org.
  • Takahashi H; National Institute of Public Health, Saitama, Japan.
  • Kaise H; Tokyo Medical University Ibaraki Medical Center, Ibakaki, Japan.
  • Yamada K; Tokyo Medical University Hachioji Medical Center, Tokyo, Japan.
  • Ueno E; Tsukuba International Breast Clinic, Ibaraki, Japan.
  • Kawate T; Tokyo Medical University Hospital, Tokyo, Japan.
  • Miyahara K; Tokyo Medical University Hospital, Tokyo, Japan.
  • Ueda A; Tokyo Medical University Hospital, Tokyo, Japan.
  • Sato S; Tokyo Medical University Hospital, Tokyo, Japan.
  • Asaoka M; Tokyo Medical University Hospital, Tokyo, Japan.
  • Okazaki M; Tokyo Medical University Hospital, Tokyo, Japan.
  • Uenaka N; Tokyo Medical University Hospital, Tokyo, Japan.
  • Orimoto K; Tokyo Medical University Hospital, Tokyo, Japan.
  • Wu R; Tokyo Medical University Hospital, Tokyo, Japan.
  • Koyama Y; Tokyo Medical University Hospital, Tokyo, Japan.
  • Ishikawa T; Tokyo Medical University Hospital, Tokyo, Japan.
Clin Breast Cancer ; 23(3): 265-271, 2023 04.
Article in English | MEDLINE | ID: covidwho-2297623
ABSTRACT

BACKGROUND:

Breast screening services were suspended for several months owing to the coronavirus disease 2019 (COVID-19) pandemic. We estimated the potential impact on breast cancer mortality using long-term global observations. However, the magnitude of the impact may vary across countries; therefore, we conducted an analysis and modeling study of this impact in Japan. PATIENTS AND

METHODS:

We compared the clinicopathological features of breast cancers between the nonpandemicgroup (April 1, 2019 to October 31, 2019) and the pandemic group (April 1, 2020 to October 31, 2020). We also compared the estimated 10-year survival rates between the two groups based on the weighted average of the 10-year survival rate by clinical stage and site (2004-2007).

RESULTS:

Results...Pandemic-related disruption decreased the number of breast cancer cases from296 to 249 during both 7-month periods. The percentage of patients with stage IIB or higher disease was significantly higher in the pandemic group than in the non-pandemic group (22.0% vs. 31.3%, P = 0.0133). The percentage of cases with a Ki-67 labeling index higher than 20% tended to be higher in the pandemic group than in the non-pandemic group (62.2% vs. 54.4%). The estimated 10-year survival rate was lower in the pandemic group than in the non-pandemic group (83.9% vs. 87.9%, 95% confidence interval of the difference 0.87-8.8, P > 0.05).

CONCLUSION:

We found more aggressive and advanced disease afterthe suspension of breast cancer screening services owing to the COVID-19 pandemic. This may have affected the long-term clinical outcomes of patients with breast cancer.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Breast Neoplasms / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Female / Humans Language: English Journal: Clin Breast Cancer Journal subject: Neoplasms Year: 2023 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Breast Neoplasms / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Female / Humans Language: English Journal: Clin Breast Cancer Journal subject: Neoplasms Year: 2023 Document Type: Article