A three-dimensional terbium metal − organic framework fluorescent sensor for efficient detection of chloroquine phosphate in serum

ABSTRACT

[Display omitted] • Tb-MOF as a potential sensing material for chloroquine phosphate recovered for multiple cycles. • The quenching mechanisms between Tb-MOF and chloroquine phosphate from many aspects investigated. • The sensor used for the visual detection of chloroquine phosphate in serum. A novel three-dimensional (3D) anionic anhydrous metal − organic framework (MOF), {[NH 2 (CH 3) 2 ]·[Tb(pdca) 2 ]} n (Tb-MOF ;H 2 pdca = 2,5-pyridinedicarboxylic acid) has been triumphantly fabricated and structurally characterized. The obtained Tb-MOF displays good stability in some common solvent systems and high temperature environments. The luminescence properties of Tb-MOF are investigated by fluorescence spectra, and the results exhibit superb characteristic emission of Tb3+ ions, which lay a foundation for exploring the fluorescence sensing application of the material. More importantly, based on competitive absorption and dynamic quenching, Tb-MOF can be applied to detect chloroquine phosphate (CQ) used for the treatment of COVID-19 and malaria, showing high sensitivity and fast response speed in the sensing process. Notably, the specific quenching effect between Tb-MOF and CQ in the serum system without interference from other components, demonstrating the practical application potential of Tb-MOF. [ FROM AUTHOR] Copyright of Microchemical Journal is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)