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Perspectives and Prospects on the application of DNA Aptamer in SARS-CoV-2.
Liu, Yunyi; Hu, Bei; Pei, Xiaming; Li, Juan; Hu, Xiaoxiao.
  • Liu Y; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Molecular Science and Biomedicine Laboratory and Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan 410082, China.
  • Hu B; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Molecular Science and Biomedicine Laboratory and Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan 410082, China.
  • Pei X; Department of Urology, Hunan Provincial Tumor Hospital, Changsha, Hunan 410013, China.
  • Li J; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Molecular Science and Biomedicine Laboratory and Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan 410082, China.
  • Hu X; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Molecular Science and Biomedicine Laboratory and Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan 410082, China.
Curr Med Chem ; 2023 Apr 08.
Article in English | MEDLINE | ID: covidwho-2299011
ABSTRACT
With the SARS-COV-2 spreading worldwide, COVID-19 has induced enormous disaster and challenges to the world public health since 2019. To development effective diagnostic and treatment methods for the SARS-CoV-2 is crucial for the control of the COVID-19 spreading. DNA aptamers, short single DNA oligonucleotides, have shown an immense application potential as molecular probes for early diagnosis and therapy of various diseases. Compared with antibodies, DNA aptamers are easier to synthesize, with high stability and low immunogenicity, which allows it to be widely and rapidly used in various bio-sensing and therapy to against COVID-19 since then. Thus, we here reviewed the development and prospected potential applications of DNA aptamers in diagnosis and treatment of SARS-COV-2.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Screening_studies Language: English Journal subject: Chemistry Year: 2023 Document Type: Article Affiliation country: 0929867330666230408193030

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Screening_studies Language: English Journal subject: Chemistry Year: 2023 Document Type: Article Affiliation country: 0929867330666230408193030