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Raman spectroscopy for viral diagnostics.
Lukose, Jijo; Barik, Ajaya Kumar; George, Sajan D; Murukeshan, V M; Chidangil, Santhosh.
  • Lukose J; Centre of Excellence for Biophotonics, Department of Atomic and Molecular Physics, Manipal Academy of Higher Education, 576104 Manipal, India.
  • Barik AK; Centre of Excellence for Biophotonics, Department of Atomic and Molecular Physics, Manipal Academy of Higher Education, 576104 Manipal, India.
  • Mithun N; Centre of Excellence for Biophotonics, Department of Atomic and Molecular Physics, Manipal Academy of Higher Education, 576104 Manipal, India.
  • Sanoop Pavithran M; Centre of Excellence for Biophotonics, Department of Atomic and Molecular Physics, Manipal Academy of Higher Education, 576104 Manipal, India.
  • George SD; Centre for Applied Nanosciences, Department of Atomic and Molecular Physics, Manipal Academy of Higher Education, 576104 Manipal, India.
  • Murukeshan VM; Centre for Optical and Laser Engineering, School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798 Singapore, Singapore.
  • Chidangil S; Centre of Excellence for Biophotonics, Department of Atomic and Molecular Physics, Manipal Academy of Higher Education, 576104 Manipal, India.
Biophys Rev ; 15(2): 199-221, 2023 Apr.
Article in English | MEDLINE | ID: covidwho-2299212
ABSTRACT
Raman spectroscopy offers the potential for fingerprinting biological molecules at ultra-low concentration and therefore has potential for the detection of viruses. Here we review various Raman techniques employed for the investigation of viruses. Different Raman techniques are discussed including conventional Raman spectroscopy, surface-enhanced Raman spectroscopy, Raman tweezer, tip-enhanced Raman Spectroscopy, and coherent anti-Stokes Raman scattering. Surface-enhanced Raman scattering can play an essential role in viral detection by multiplexing nanotechnology, microfluidics, and machine learning for ensuring spectral reproducibility and efficient workflow in sample processing and detection. The application of these techniques to diagnose the SARS-CoV-2 virus is also reviewed. Supplementary Information The online version contains supplementary material available at 10.1007/s12551-023-01059-4.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study Language: English Journal: Biophys Rev Year: 2023 Document Type: Article Affiliation country: S12551-023-01059-4

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study Language: English Journal: Biophys Rev Year: 2023 Document Type: Article Affiliation country: S12551-023-01059-4