Post Covid-19 Syndrome Dysautonomia: A Tertiary Referral Centre Experience
Journal of Neurology, Neurosurgery and Psychiatry
; 93(9):24, 2022.
Article
in English
| EMBASE | ID: covidwho-2299498
ABSTRACT
Post-coronavirus disease 19 (COVID-19) syndrome has substantial health and economic implications. It is multi-systemic, with prevalent autonomic symptoms. Understanding presentations and potential autonomic causes may help guide treatment strategies and recovery. All patients with a suspected or confirmed history of COVID-19 infection who underwent autonomic testing between May 2020 and October 2021 were reviewed retrospectively. We evaluated 62 patients (20 male, 42 female, mean age of 41.38 +/-11.52). COVID-19 was PCR confirmed in 15 patients (26%), and five (8%) required acute hospital intervention. Most common symptoms included palpitations (81%), lightheadedness/ dizziness (62%), dyspnoea (48%), fatigue (46%), or cognitive symptoms (33%) Autonomic testing showed normal blood pressure responses to pressor stimuli, a mean respiratory sinus arrhythmia of 18.89b/m, and Valsalva ratio of 2.09. Postural tachycardia syndrome (PoTS) was diagnosed in 12 patients, autonomically mediated syncope (AMS) in 11, neurogenic orthostatic hypotension (NOH) in two, and initial orthostatic hypotension (IOH) in seven. Normal supine and upright plasma noradrenaline levels were measured in 34 patients (mean 283.38 pg/ml supine;472.43pg/ml tilted). Autonomic testing was reassuring (PoTS and syncope) in the majority with abnormal testing (n=32, or 52%). Further phenotyping of PoTS to exclude neuropathic pathology may be needed. IOH and OH are important considerations.
adult; autonomic dysfunction; blood pressure monitoring; clinical evaluation; cognition; conference abstract; controlled study; coronavirus disease 2019; dizziness; dyspnea; faintness; fatigue; female; heart palpitation; human; human tissue; long COVID; major clinical study; male; noradrenalin blood level; orthostatic hypotension; phenotype; postural orthostatic tachycardia syndrome; respiratory sinus arrhythmia; retrospective study; tertiary care center; Valsalva maneuver; hypertensive factor
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Topics:
Long Covid
Language:
English
Journal:
Journal of Neurology, Neurosurgery and Psychiatry
Year:
2022
Document Type:
Article
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