Saturation time of exposure interval for cross-neutralization response to SARS-CoV-2: implications for vaccine dose interval
iScience
; 2023.
Article
in English
| EuropePMC | ID: covidwho-2300191
ABSTRACT
Evaluating the serum cross-neutralization responses after breakthrough infection with various SARS-CoV-2 variants provides valuable insight for developing variant-proof COVID-19 booster vaccines. However, fairly comparing the impact of breakthrough infections with distinct epidemic timing on cross-neutralization responses, influenced by the exposure interval between vaccination and infection, is challenging. To compare the impact of pre-Omicron to Omicron breakthrough infection, we estimated the effects on cross-neutralizing responses by the exposure interval using Bayesian hierarchical modeling. The saturation time required to generate saturated cross-neutralization responses differed by variant, with variants more antigenically distant from the ancestral strain requiring longer intervals of 2-4 months. The breadths of saturated cross-neutralization responses to Omicron lineages were comparable in pre-Omicron and Omicron breakthrough infections. Our results highlight the importance of vaccine dosage intervals of 4 months or longer, regardless of the antigenicity of the exposed antigen, to maximize the breadth of serum cross-neutralization covering SARS-CoV-2 Omicron lineages. Graphical
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Collection:
Databases of international organizations
Database:
EuropePMC
Type of study:
Randomized controlled trials
Topics:
Vaccines
Language:
English
Journal:
IScience
Year:
2023
Document Type:
Article
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