Your browser doesn't support javascript.
The impact of SARS-CoV2 vaccines on the incidence of graft versus host disease in allogeneic hematopoietic stem cell transplant recipients: a single-center retrospective study.
Ngo, Dat; Chen, Jason; Tinajero, Jose; Aribi, Ahmed; Arslan, Shukaib; Marcucci, Guido; Nakamura, Ryotaro; Al Malki, Monzr M; Forman, Stephen J; Dadwal, Sanjeet; Ali, Haris.
  • Ngo D; Department of Pharmacy, City of Hope Medical Center, 1500 E. Duarte Road, Duarte, CA, 91010, USA.
  • Chen J; Department of Pharmacy, City of Hope Medical Center, 1500 E. Duarte Road, Duarte, CA, 91010, USA. jaschen@coh.org.
  • Tinajero J; Department of Pharmacy, City of Hope Medical Center, 1500 E. Duarte Road, Duarte, CA, 91010, USA.
  • Aribi A; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA.
  • Arslan S; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA.
  • Marcucci G; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA.
  • Nakamura R; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA.
  • Al Malki MM; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA.
  • Forman SJ; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA.
  • Dadwal S; Department of Infectious Diseases, City of Hope, Duarte, CA, USA.
  • Ali H; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA.
Stem Cell Res Ther ; 14(1): 95, 2023 04 18.
Article in English | MEDLINE | ID: covidwho-2300884
ABSTRACT
This study reports the incidence of chronic graft versus host disease (GvHD) in allogeneic hematopoietic stem cell transplant (alloHCT) recipients who received SARS-CoV2 vaccination. The overall rates of new and worsening chronic GvHD combined were 14%, with median time from vaccination to GVHD being approximately three to four weeks. A majority of the cases were of mild to moderate severity and primarily localized to either the skin, mouth, or joints. Prior chronic GVHD and recent transplant were associated with higher GVHD rates following COVID-19 vaccination. More prospective studies are needed to provide a definitive mechanism for the impact of SARS-CoV2 vaccination on alloHCT patients.
Subject(s)
Keywords
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: Hematopoietic Stem Cell Transplantation / COVID-19 Vaccines / COVID-19 / Graft vs Host Disease Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Stem Cell Res Ther Year: 2023 Document Type: Article Affiliation country: S13287-023-03326-3

Similar

MEDLINE
LILACS
LIS
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: Hematopoietic Stem Cell Transplantation / COVID-19 Vaccines / COVID-19 / Graft vs Host Disease Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Stem Cell Res Ther Year: 2023 Document Type: Article Affiliation country: S13287-023-03326-3