Your browser doesn't support javascript.
C-Reactive Protein (CRP): A Potent Inflammation Biomarker in Psychiatric Disorders.
Orsolini, Laura; Pompili, Simone; Volpe, Umberto.
  • Orsolini L; Unit of Clinical Psychiatry, Department of Clinical Neurosciences/DIMSC, Polytechnic University of Marche, Ancona, Italy. l.orsolini@staff.univpm.it.
  • Pompili S; Unit of Clinical Psychiatry, Department of Clinical Neurosciences/DIMSC, Polytechnic University of Marche, Ancona, Italy.
  • Volpe U; Unit of Clinical Psychiatry, Department of Clinical Neurosciences/DIMSC, Polytechnic University of Marche, Ancona, Italy.
Adv Exp Med Biol ; 1411: 135-160, 2023.
Article in English | MEDLINE | ID: covidwho-2301272
ABSTRACT
An increasing number of studies have investigated the role of inflammation in psychiatric disorders, by demonstrating how an altered/dysfunctional immunological and inflammatory system may underpin a psychiatric condition. Particularly, several studies specifically investigated the role of a neuroinflammatory biomarker, named C-reactive protein (CRP), in psychiatric disorders. Overall, even though scientific literature so far published still does not appear definitive, CRP is more likely reported to be elevated in several psychiatric disorders, including schizophrenia, mood disorders, anxiety disorders and post-traumatic stress disorder. Moreover, a low-grade inflammation (CRP >3 mg/L) has been more likely observed in a subgroup of patients affected with a more severe psychopathological symptomatology, more treatment resistance and worst clinical mental illness course, strengthening the hypothesis of the need for a different clinical and prognostic characterization based on this concomitant neuroinflammatory predisposition. However, even though further research studies are needed to confirm this preliminary evidence, CRP may represent a potential clinical routine biomarker which could be integrated in the clinical routine practice to better characterize clinical picture and course as well as address clinicians towards a personalized treatment.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Schizophrenia / Stress Disorders, Post-Traumatic Type of study: Diagnostic study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Adv Exp Med Biol Year: 2023 Document Type: Article Affiliation country: 978-981-19-7376-5_7

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Schizophrenia / Stress Disorders, Post-Traumatic Type of study: Diagnostic study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Adv Exp Med Biol Year: 2023 Document Type: Article Affiliation country: 978-981-19-7376-5_7