A Low-cost Handheld Reconfigurable Impedimetric Readout System for Diagnostics of Viral Infections
IEEE Transactions on Instrumentation and Measurement
; : 1-1, 2023.
Article
in English
| Scopus | ID: covidwho-2301306
ABSTRACT
This paper presents a portable impedimetric biosensor for detecting infectious diseases such as SARS-CoV-2 Infections. A bio-ready sensing electrode functionalized with SARS-CoV-2 nucleocapsid antibody was employed to quantitatively convert the concentration of nucleocapsid protein (N-protein) into impedance changes. In this paper, we proposed a readout system with a dynamic input range of 200 Ωto 1 MΩmagnitude and 0 to 180°phase. The resolution of this device is 1% and 6.5°for measuring the magnitude and phase, respectively. Herein we demonstrate and discuss the proposed system’s functionality, sensitivity, and selectivity using the clinical swab samples. As per these results, this readout system is suitable for the detection of N-protein ranging up to 10,000 pg/mL with a resolution of 56 fg/mL. The proposed impedimetric sensing system can be adopted for the detection of infectious diseases in the future. This low-cost (<$80) device using off-the-shelf is a unique candidate for batch production purposes during urgent pandemic situations. IEEE
Antibodies; Biosensor; COVID-19; Electrodes; Electronic readout system; Impedance; Impedance measurement; Integrated circuits; SARS-CoV-2; Sensors; Biosensors; Costs; Diagnosis; Electric impedance measurement; Readout systems; Timing circuits; Electronic read-out systems; Handhelds; Infectious disease; Low-costs; Nucleocapsid proteins; Reconfigurable; Viral infections; Coronavirus
Full text:
Available
Collection:
Databases of international organizations
Database:
Scopus
Language:
English
Journal:
IEEE Transactions on Instrumentation and Measurement
Year:
2023
Document Type:
Article
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