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COVID-19 related ICU admissions in paediatric and young adult patients in Australia: a national case series 2020–2022
The Lancet regional health Western Pacific ; 2023.
Article in English | EuropePMC | ID: covidwho-2301322
ABSTRACT
Background COVID-19 pandemic research efforts have focused on disease phenotypes in adults. A distinct spectrum of illness has been documented in paediatric populations. We aimed to review paediatric intensive care unit (ICU) admissions in Australia, across differing variant predominant phases of the pandemic. Methods Data reported to the Short PeRiod IncideNce sTudy of Severe Acute Respiratory Infection (SPRINT-SARI) Australia, across 49 ICUs from February 2020 to June 2022 were extracted. We defined ‘child' as patients aged <12 years, ‘adolescent' as patients aged 12–17 years, and ‘young adult' as patients aged 18–25 years. Findings We identified 226 paediatric ICU admissions with COVID-19, representing 3.9% of ICU admissions across the study period. Comorbidity was present in 34.6% of children, 51.4% of adolescents, and 48.7% of young adults. The need for respiratory support was highest in young adults. While 28.3% of patients <18 years required invasive ventilation, in-hospital mortality in paediatric patients was 3.6%. During the Omicron period, there was an increase in the annualised incidence of age-specific COVID-19 ICU admissions per 100,000 population, albeit a decrease in the incidence per 1000 SARS-CoV-2 notifications. Interpretation This study demonstrated an appreciable burden of COVID-19 in paediatric patients. Adolescent patients presented phenotypically similar to young adults, however, illness severity was lower in younger cohorts. The Omicron phase of the pandemic demonstrated an increased age-specific population incidence of COVID-19 ICU admissions, albeit a reduced incidence when based on SARS-CoV-2 notifications. Funding SPRINT-SARI Australia is supported by the 10.13039/501100003921Department of Health, Commonwealth of Australia [Standing Deed SON60002733].
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Collection: Databases of international organizations Database: EuropePMC Language: English Journal: The Lancet regional health Western Pacific Year: 2023 Document Type: Article

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Collection: Databases of international organizations Database: EuropePMC Language: English Journal: The Lancet regional health Western Pacific Year: 2023 Document Type: Article