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DNA immunization with in silico predicted T-cell epitopes protects against lethal SARS-CoV-2 infection in K18-hACE2 mice.
Persson, Gry; Restori, Katherine H; Emdrup, Julie Hincheli; Schussek, Sophie; Klausen, Michael Schantz; Nicol, McKayla J; Katkere, Bhuvana; Rønø, Birgitte; Kirimanjeswara, Girish; Sørensen, Anders Bundgaard.
  • Persson G; Evaxion Biotech A/S, Hoersholm, Denmark.
  • Restori KH; Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA, United States.
  • Emdrup JH; Evaxion Biotech A/S, Hoersholm, Denmark.
  • Schussek S; Evaxion Biotech A/S, Hoersholm, Denmark.
  • Klausen MS; Evaxion Biotech A/S, Hoersholm, Denmark.
  • Nicol MJ; Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA, United States.
  • Katkere B; Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA, United States.
  • Rønø B; Evaxion Biotech A/S, Hoersholm, Denmark.
  • Kirimanjeswara G; Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA, United States.
  • Sørensen AB; Evaxion Biotech A/S, Hoersholm, Denmark.
Front Immunol ; 14: 1166546, 2023.
Article in English | MEDLINE | ID: covidwho-2301745
ABSTRACT
The global SARS-CoV-2 pandemic caused significant social and economic disruption worldwide, despite highly effective vaccines being developed at an unprecedented speed. Because the first licensed vaccines target only single B-cell antigens, antigenic drift could lead to loss of efficacy against emerging SARS-CoV-2 variants. Improving B-cell vaccines by including multiple T-cell epitopes could solve this problem. Here, we show that in silico predicted MHC class I/II ligands induce robust T-cell responses and protect against severe disease in genetically modified K18-hACE2/BL6 mice susceptible to SARS-CoV-2 infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines, DNA / COVID-19 Type of study: Prognostic study Topics: Vaccines / Variants Limits: Animals Language: English Journal: Front Immunol Year: 2023 Document Type: Article Affiliation country: Fimmu.2023.1166546

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines, DNA / COVID-19 Type of study: Prognostic study Topics: Vaccines / Variants Limits: Animals Language: English Journal: Front Immunol Year: 2023 Document Type: Article Affiliation country: Fimmu.2023.1166546