Biological age is increased by stress and restored upon recovery.
Cell Metab
; 35(5): 807-820.e5, 2023 05 02.
Article
in English
| MEDLINE | ID: covidwho-2301903
ABSTRACT
Aging is classically conceptualized as an ever-increasing trajectory of damage accumulation and loss of function, leading to increases in morbidity and mortality. However, recent in vitro studies have raised the possibility of age reversal. Here, we report that biological age is fluid and exhibits rapid changes in both directions. At epigenetic, transcriptomic, and metabolomic levels, we find that the biological age of young mice is increased by heterochronic parabiosis and restored following surgical detachment. We also identify transient changes in biological age during major surgery, pregnancy, and severe COVID-19 in humans and/or mice. Together, these data show that biological age undergoes a rapid increase in response to diverse forms of stress, which is reversed following recovery from stress. Our study uncovers a new layer of aging dynamics that should be considered in future studies. The elevation of biological age by stress may be a quantifiable and actionable target for future interventions.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
Limits:
Animals
/
Humans
Language:
English
Journal:
Cell Metab
Journal subject:
Metabolism
Year:
2023
Document Type:
Article
Affiliation country:
J.cmet.2023.03.015
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