Novel coronavirus disease-19:An overviwe of pathogenesis, health influences and measures
Health Biotechnology and Biopharma
; 4(2):28-36, 2020.
Article
in English
| EMBASE | ID: covidwho-2302193
ABSTRACT
The coronavirus disease-19 (COVID-19) signs mostly include fever and respiratory symptoms (unusual viral pneumonia by SARS-Coronaviruses 2 or SARS-CoV-2). The Receptor-Binding Domain (RBD) of COVID-19 and SARS-CoV are similar, causing cross-reactivity of anti-SARSCoV antibodies with associated spike protein, exerting promising implications for rapid development of vaccines and therapeutic antibodies against COVID-19. ACE2 is the SARS TMPRSS2 for spike (S) protein receptor for initiation of infection;hence, it is a target for pharmacological intervention. Furthermore, designing novel monoclonal antibodies binding specifically to COVID-19 RBD is essential. A viral S proteins (TMPRSS2) was proposed for clinical use by blocking the viral intake by cell.Copyright © 2020, Health Biotechnology and Biopharma. All rights reserved.
Control; Corona virus disease-19; Prevention; Virulence; adult respiratory distress syndrome; age; article; clinical feature; coronavirus disease 2019/dt [Drug Therapy]; coronavirus disease 2019/et [Etiology]; coronavirus disease 2019/pc [Prevention]; cross reaction; dyspnea; heart injury; home care; human; infection control; infection prevention; nonhuman; pathogenesis; priority journal; receptor binding; Severe acute respiratory syndrome coronavirus 2; shock; virology; virus transmission; virus virulence; coronavirus spike glycoprotein/ec [Endogenous Compound]; SARS-CoV-2 antibody/ec [Endogenous Compound]; SARS-CoV-2 vaccine/dt [Drug Therapy]
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Language:
English
Journal:
Health Biotechnology and Biopharma
Year:
2020
Document Type:
Article
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